TheU.S. National Science Foundation National Synthesis Center for Emergence in the Molecular and Cellular Sciences (NCEMS)and theInstitute for Computational and Data Sciences(ICDS)at Penn State seeks an outstanding scientist to fill a Machine Learning Staff Scientist (Research Data Scientist - Intermediate Professional) position dedicated to advancing the collaborative research of the CentersWorking Groups.

NCEMS is an interdisciplinary research Center positioned at the interface of data science with molecular and cellular biology. The Center provides leadership in the integration of diverse publicly available datasets enabling cross-disciplinary teams of scientists to synthesize knowledge and pursue fundamental questions at the forefront of the life sciences.

About the Position: Machine Learning Staff Scientists play a supporting role in enabling the research efforts of multidisciplinary scientific teams supported by NCEMS typically contributing to 2-3 projects simultaneously.

Work Arrangement: This position has the potential to be a hybrid of remote and on-site work with a minimum requirement of 3 days per week on-site at the Penn State University Park campus. This position does notpermitfully remote work.

Responsibilities:

• Collaborate with NCEMS Working Groups to design develop and evaluate machine learning approaches for integrating analyzing and visualizing molecular and cellular biology data across the central dogma and regulatory processes.

• Prepare ML-ready datasets by leading data wrangling harmonization standardization quality control and documentation to support robust training and reuse across biological modalities.

• Develop end-to-end ML workflows (feature/representation learning training validation benchmarking and uncertainty quantification) for multi-omics and related data types.

• Build andoptimizepredictive and generative models (e.g. deep learning probabilistic models foundation-model adaptation graph/neural sequence models) to support synthesis research questions.

• Implement scalable training and inference pipelines using modern ML tooling (e.g.PyTorch/TensorFlow/JAX) version control containers and HPC/GPU resources.

• Support the publication of intermediate data products models code and documentation.

• Stayup-to-datewith the latest advancements in machine learning AI for biology and the rapidly evolving landscape of public molecular and cellular datasets.

Education and Experience:

• M.S. or PhD in Machine Learning Computational Biology Bioinformatics Computer Science Statistics Data Science or a related fieldis preferred.

• Strongproficiencyin Python for scientific computing and machine learning including experience with common ML libraries/frameworks (e.g.PyTorch TensorFlow JAX scikit-learn).

• Demonstrated experience and understanding of core machine learning deep learning and statistical methods such as: regression and generalized linear models; classification and clustering; dimensionality reduction; sequence and time-series modeling; deep learning architectures including CNNs RNNs GNNs and transformers; generative modeling (e.g. diffusion and variational/auto-regressive approaches) representation learning and self-/weakly-supervised learning natural language processing computer vision and causal inference.

• Experience working with high-dimensional large-scale molecular and cellular datasets (e.g. genomic transcriptomic epigenomic proteomic metabolomic/lipidomic imaging-derived single-cell or multi-omics data) includingappropriate preprocessingand normalization strategies for ML.

• Solid understanding of molecular and cellular biology concepts sufficient to frame ML problems across the central dogma (sequence expression regulation and protein function/structure) and to collaborate effectively with domain scientists.

• Experience with software engineering practices for research-grade code version control (Git) reproducible environments (containers/conda) HPC/GPU computing.

• Publications in peer-reviewed journalsdemonstratingcontributions to the field.

• Experience supporting/contributing to multi-PI projects.

Candidates must alsodemonstratea commitment to ethical conduct and research integrity strong work ethic strong interpersonal and written communication skills and the ability to work well in a team environment.

Applicaiton materials: Required documents include the following:

• A current Curriculum Vitae (CV) or Resume

• A cover letter detailing the candidates interest in the role

Benefits:

Penn State provides a competitive benefits package for full-time employees designed to support both personal and professional well-being. For more detailed information please visitourBenefits Page.