Senior Research Scientist, Chemical Biology & Proteomics

We areseekingahighly motivatedandtalentedscientist to join ourChemicalBiology & Proteomics(CBP)teamat AstraZeneca in Waltham MA.As aSenior Research Scientist youwill be an integral member of a team generating pre-clinical pharmacology data to understandefficacyand selectivityof therapeutic agents. You will have the opportunity to work witha team ofcross-functionalscientists and support the development of new and successful therapiesfor patients.Ifyoureinspired by the possibilities of science to make a difference and ready to discover what you can do join us.

KeyResponsibilities

• Develop andemploychemicaltoolsandproteomicstechnologies toprovideimpactfulmechanisticinsightsfordrug discoveryprojectsacrosstherapeutic areas

• Develop mass spectrometry-based methodsto conductcovalentscreens

• Design and execute experimental plans to understandtarget engagementandselectivityprofilesof therapeutic agentsunderstand drug-induced proteomedynamicsand investigatepost-translational modifications (PTM)

• Represent CBP team and communicate withprojectdiscipline leads andcontribute togeneration ofmechanistic hypothesisthroughinterpretation of sophisticated proteomics data

• Maintainand troubleshootLC-MSsystem

Essential Requirements

• PhD with2 yearsof post-doctoral/industrialexperience

• Knowledge and hands-on experience with sample preparation and method development on quantitative mass spectrometry (relative and/orabsoluteproteinquantification)

• Experience with mass spectrometry-based covalent screening and provenexpertisewith IP-MS or chemical probe-basedenrichment MSworkflowsandexperiencedeveloping automated processes to analyzelarge numberof samplesforMS analysis

• Skilled ininvestigatingcompound effectsunder biochemical and cellular settingswith quantitativemass spectrometrye.g.PTMs protein complexes perturbationsetc

• Experience indeterminingprotein abundanceand turnoverby using quantitative proteomicstechnologies such as TMT SILACand/orlabel-free approaches and data independent acquisition (DIA)

• Expertisein data analysis and an ability to communicate data interpretation clearly

• Significant external reputation gained through professional recognition externalpresentationsand publicationsin high-impact journals

• Ability to contribute with a positive result oriented andproblem-solving attitude

Desirable Requirements

• Experience in pre-clinical drug discovery

• Experience usingThermoQ-ExactiveOrbitrapExplorisEclipseAstralZoomorTimsTOF

• ExperiencewithXcalibur Proteome DiscovererMaxQuant SkylineSpectronautand DB search engine tools

• Experience with liquid handling systems and robotic automation

• Familiarity with targeted proteomics is a plus

Why AstraZeneca

At AstraZeneca we re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There is no better place tomake a difference to medicinepatientsand society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learninggrowthand development.

Next Steps Apply today!

To be considered for this exciting opportunity please complete the full application on our website at your earliest convenience it is the only way that our Recruiter and Hiring Manager can know that you feelwell qualifiedfor this opportunity. If you know someone who would be a great fit please share thispostingwith them.