Scientist Bioscience in vivo, Respiratory and Immunology

AstraZeneca is a global science-driven biopharmaceutical company. We are dedicated to discovering developing and delivering innovative meaningful medicines and healthcare solutions that enrich the lives of patients. The vision ofAstraZeneca Respiratory & Immunology (R&I)iscenteredon delivering life-changing products that advance world health and help fight and cure disease. R&I is one of three main therapeutic research areas within AstraZeneca that deliver candidate drugs into late-stage clinical development. We are building new capabilities to support our growth in immunology and autoimmune diseases and we have an exciting opportunity for an in vivo scientist looking to help bring new medicines to patients.

As a part of a growing in vivo Bioscience team within the R&I department we areseekinga highly motivatedscientistwithhands-on in vivo skillsto join our collaborative team. This candidate would have experience in immunology or related discipline. This is a lab-based position. The role will initially be based in Waltham MA within AstraZenecasstate-of-the-artlaboratories where you will follow the science to help drive innovation and advance medicine to help improve patient October2026 we will belocatedat the newstate of the artfacilities in Kendall Square Cambridge.

Main Duties and Responsibilities

In this role you will be anin vivoexperimental scientist within Respiratory and Immunology Department focusing on developing therapeutics for the treatment of immune and autoimmune diseases such as SLEfibrosisand arthritis using mouse models. You will generate preclinical and translational data in support of key portfolio programs and drive technical excellence in bioscience research.Strongexpertisein in vivo mouse modelsandhands-on in vivo skillsisand multiparameter flow cytometry multiplex cytokine read-outs qPCR is essential. The role will sometimes involve implementing protocols over timelines that extend outside of normal working patterns.

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Accountabilities and responsibilities:

• Excellent hands-on in vivo skills and the ability to independently run disease and mechanistic models including administering candidate drugs and collecting a rangeofbiological samples.

• Responsible formaintainingthe highest standards of animal welfare and ethical compliance as well as data integrity.

• Depending on experienceyou may be assigned as in vivo lead for studies supporting pre-clinical discovery and early development projects.

• Design and develop disease-relevant in vivo models and biomarkers

• Contribute to the evaluation and interpretation of primary data as well as writing reports and summaries.

• Supporting drug discovery projects to meet theirobjectivesby acting as an effective and creative team member.

Essential requirements

• Masters degreein biology immunology or relevant disciplineand5years of relevant industry experiencewith extensiveproventrack recordof in vivo work.

• Practical In vivo experience and experimental skills in the use of animal modelsand tissue processingincluding mice handlinginjections(IPIVSCID) PO dosing blood collection. Tissue harvesting and processing for downstreamanalysis.

• Experience inmolecular andcellular biology techniques includingRT-PCRELISAmulti-parameterflowcytometryand assaydevelopment.

• Good understanding of pharmacologyphysiologyand immunology.

• Analytical skills related to in vivo research and data analysis.

• Good written and oral communication skills in English.

• As highly motivated independent scientist - be able to work effectively as part of a team and develop ideas by incorporating the views of others.

• Able to communicate effectively across language cultural or other barriers.

• Understanding of statistical methods quality control including data reporting and archiving.

Desirable requirements

• Immunology/autoimmunedisease knowledge including target and mechanism knowledge (e.g. SLE arthritisSjogrens)

• Experience with humanized mice models

Why Join Us

As part of AstraZenecas dynamic US biologics R&D community you will play a critical role in shaping the future of AI-driven biologics discovery and engineering. Collaborating across cutting-edge computational and experimental teams youll drive innovation that brings transformative medicines to patients around the world. You will be supported by a collaborative inclusive and empowering environment with unparalleled opportunities for scientific impact and personal growth.