Off-Target Biology and Genomics Scientist Gene Therapy

• Lead and execute genomic safety assessment packages for gene editing therapeutics spanning off-target discovery verification/validation and genomic integrity characterization.
• Apply and evaluate a range of off-target discovery approaches including in silico tools (CALITAS CRISPRMe CasOFFinder) biochemical methods (SITE-seq CIRCLE-seq CHANGE-seq Digenome-seq) and cell-based assays (GUIDE-seq INDUCE-seq).
• Drive off-target verification and validation using amplicon-based sequencing approaches such as AmpSeq rhAmpSeq and hybrid capture sequencing.
• Characterize genomic integrity using orthogonal methods including karyotyping optical genome mapping and WGS.
• Assess genotoxicity potential of next-generation genome engineering modalities (base editors prime editors) using modality-appropriate off-target assessment strategies.
• Contribute to or lead novel assay development efforts to interrogate emerging genome editing modalities (Gen 5)
• Integrate biodistribution data to guide tissue selection for off-target verification studies

Qualifications :

Minimum Required Qualifications:

• B.S. in genomics molecular biology biochemistry or a related field with 5 years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics. M.S. in genomics molecular biology biochemistry or a related field with 3-7 years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics. Ph.D. in genomics molecular biology biochemistry or related field with 2-4 years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics.
• Proficiency with CRISPR-based genome editing and familiarity with a broad range of off-target discovery platforms.
• Experience with next-generation sequencing workflows and data interpretation.
• Familiarity with emerging modalities such as base editing and prime editing and their associated genotoxicity considerations.
• Strong track record of scientific problem-solving with experience in assay development being a plus.
• Excellent written and verbal communication skills; ability to present complex data to cross-functional teams.
• Ability to work independently and as a part of a team self-motivation adaptability and a positive attitude.

Preferred Qualifications:

• Experience with optical genome mapping (Bionano platform).
• Familiarity with regulatory expectations around genomic safety packages for IND/BLA submissions.
• Experience with human diversity-dependent off-target discovery approaches (e.g. ONE-seq).
• Authorization to work in the United States indefinitely without restriction or sponsorship.

Additional Information :

The position is Full Time Monday-Friday 8 am-5 pm. Candidates currently living within a commutable distance of Boston MA are encouraged to apply

What to Expect in the Hiring Process:

• 10-15 Minute Phone Interview with Regional Recruiter
• 45-60 Minute Virtual Interview with Manager and/or Group Leader
• 45-60 Minute In-Person Meeting for a Casual Discussion of the Role

What We Offer:

• Excellent full-time benefits including comprehensive medical coverage dental and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays
• Yearly goal-based bonus & eligibility for merit-based increases
• Annual Compensation is $104000 - $112320 depending on education and experience 

Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.

Remote Work :

No

Employment Type :

Full-time