Executive Director, Early Differentiation & Pipeline, Global Medical Neuroscience

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Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits services and programs that provide our employees with the resources to pursue their goals both at work and in their personal lives. Read more: Executive Director Early Differentiation & Pipeline (EDAP) Global Medical Neuroscience will lead the earlystage medical strategy to differentiate pipeline assets and accelerate highvalue programs from discovery through key governance milestones. This role shapes integrated evidence strategies (clinical and realworld) defines target product profiles (TPPs) advances biomarker/diagnostic and personalized care approaches and drives crossfunctional portfolio decisions that maximize launch readiness patient access and longterm lifecycle value across Neuroscience with strategic alignment to Neuroscience portfolio.

The leader will steward external scientific engagement research collaborations and scientific communications. while leading and coaching a highperforming Early Asset Medical team. The Executive Director Global Medical Neuroscience EDAP will lead a team of Medical Strategy leads and Medical Product Leads (MPLs) and reports directly to the SVP Global Head of Medical Affairs Neuroscience will be key part of the Medical Neuroscience leadership team. This role will focus specifically on early pipeline assets in Phase 1 and Phase 2 signal-seeking development maintaining dynamic prioritization of assets in partnership with discovery and early development teams to ensure efforts are invested in the most promising assets.

Key Responsibilities

Early Pipeline Differentiation & Evidence Strategy

• Collaborate with Discovery Early Development Translational Research and Early Transition Assets on biomarker/diagnostic strategies and personalized care approaches with particular emphasis on neuroimaging technologies digital endpoints and companion diagnostics (CDx) as well as their potential clinical applicability/utility.

• Understand the role of biomarkers neuroimaging digital endpoints and diagnostic platforms in determining treatments across neurological diseases and integrate this understanding into early program strategic approaches.

• Lead creation of early Integrated Evidence Plans (IEPs) that differentiate clinical endpoints and realworld outcomes.

• Shape IEPs and CCF plans beyond regulatory minimums to address unmet needs. Provide key input to define optimal Target Product Profiles (TPPs).

• Inform and accelerate governance decisions on priority programs to ensure maximum transformational clinical value is captured via Clinical Development Plans (CDP) and Integrated Evidence Plans (IEP).

• Represent medical perspective in business development and licensing activities.

• Make recommendations to research and clinical development teams based on external landscape and insights from scientific partnerships and external experts.

• Ensure deep local and stakeholder insights inform pipeline shaping.

Portfolio Shaping Governance & Prioritization

• Drive crossfunctional shaping across Neuroscience portfolios.

• Deliver earlyprogram strategic assessments to prioritize transformational assets.

• Establish crossasset medical strategies maximizing lifecycle value and patient access.

• Maintain an ongoing dynamic prioritization of assets in partnership with discovery and early development teams to ensure efforts are invested in the most promising asset.

• Ensure global alignment of medical strategic priorities across the Medical Matrix.

Evidence Generation Access & Operations.

• Partner with Medical Evidence Generation (MEG) Global Drug Development (GDD) Global Development Operations (GDO) Health Economics and Outcomes (HEOR) and Disease Area Heads (DAH) on portfoliolevel evidence strategies.

• Align with Markets and Disease Area Leads on evidence generation priorities.

• Collaborate with Market Access/HEOR on HTArelevant strategies and data gaps.

• Integrate GDO and Regional Clinical Operations (RCO) to ensure feasibility and operational excellence.

• Identify and execute opportunities for medical affairs-enabled signal generation for priority assets leveraging internal organization as well as external trusted centers of excellence.

External Engagement Collaborations & Communications

• Build early scientific partnerships councils and research collaborations at top centers of excellence for neuroscience research.

• Identify and enable preclinical translational clinical Real-World Evidence (RWE) and digital health collaborations.

• Drive early medical expert and scientific engagement globally.

• Ensure strong Scientific Communications plans across therapeutic areas including comprehensive publication planning integrated into priority asset plans.

• Oversee early pipeline strategy for medical congresses and ensure pipeline scientific communications are tied to strategy for all congresses.

• Partner on omnichannel Artificial Intelligence / Machine Learning (AI/ML) and analyticsdriven solutions.

• Leverage novel approaches to integrating patient journey insights into early compound differentiation strategies.

• Support HTA and reimbursementrelated scientific engagements.

• Oversee the Asset Integrated Medical Teams (AIMs) to ensure asset strategies reflect global needs.

Early Pipeline Medical Leadership

• Lead a team of senior medical affairs professionals focused on early Neuroscience assets ensuring optimal differentiation clinical value and strategic fit to clinic.

• Shape the early Neuroscience portfolio narrative and communicate strategy clearly to internal and external stakeholders.

• Leverage a strong understanding of the medical landscape neuroscience disease biology and medical affairs strategies for early-phase assets.

• Bring a patient lens and perspective to early development and ensure plans are reviewed with external stakeholders.

• Partner with cross-functional teams to create a clear and compelling scientific story for portfolio and individual compounds.

• Provide leadership in relation to biomarkers neuroimaging digital endpoints and companion diagnostics as well as potential clinical applicability/utility.

• Enhance the differentiated clinical value and leadership of our early portfolio by shaping the design and implementation of innovative biomarker solutions neuroimaging technologies digital health tools diagnostic platforms software and big data solutions and strategic collaborations.

Compliance/Standards

• Adherence to job specific SOP and work instructions completion of assigned SOPs and training within designated timeframe and adheres to job-specific SOPs.

• Conducts business in accordance with BMS Values.

Qualifications & Experience

• Education: Medical Degree (MD or equivalent) PhD or PharmD required

• Experience: 10 years of diverse experience in development clinical or medical affairs roles. 5 years Neuroscience-specific experience (neurodegeneration neuropsychiatry neuroinflammation etc.). Previous commercial launch experience preferably at local country level. Experience in early-phase clinical development or translational science preferred. Prior experience in either Medical or Development preferred.

• Minimum 10 years of leadership experience in the pharmaceutical/life sciences industry and in academic neurological clinical service and neuroscience research with considerable experience with stakeholders and organizational engagement or partnerships (public and/or private) within neurology and neuroscience. Excellent track record in impactful scientific neuroscience and Alzheimers disease research output (publications) preferred.

• Industry Knowledge: Strong understanding of the biopharma drug development and commercialization process. Prior commercial experience and launch exposure advantageous. General knowledge of pharmaceutical operations i.e. advocacy medical affairs clinical development regulatory. Experience in business development or due diligence preferred.

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If you come across a role that intrigues you but doesnt perfectly line up with your resume we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job such as required skills where the job is performed the employees work schedule job-related knowledge and experience. Final individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits please visit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical pharmacy dental and vision care.

• Wellbeing Support: Programs such as BMS Well-Being Account BMS Living Life Better and Employee Assistance Programs (EAP).

• Financial Well-being and Protection: 401(k) plan short- and long-term disability life insurance accident insurance supplemental health insurance business travel protection personal liability protection identity theft benefit legal support and survivor support.

Work-life benefits include:

Paid Time Off

• US Exempt Employees: flexible time off (unlimited with manager approval 11 paid national holidays (not applicable to employees in Phoenix AZ Puerto Rico or Rayzebio employees)

• Phoenix AZ Puerto Rico and Rayzebio Exempt Non-Exempt Hourly Employees: 160 hours annual paid vacation for new hires with manager approval 11 national holidays and 3 optional holidays

Based on eligibility* additional time off for employees may include unlimited paid sick time up to 2 paid volunteer days per year summer hours flexibility leaves of absence for medical personal parental caregiver bereavement and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours depending on the nature of their work and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors leased workers and other service providers are not eligible to participate in the program.

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