GMP Production Manager — Advanced Therapy Medicinal Products (ATMPs) HSJD Ref. 75-2026

Hospital Sant Joan de Déu

SJD Barcelona Childrens Hospital is one of the leading Europeans centres for Obstetric Gynaecological and Paediatric centre is noted for itshigh level of specialisation and technology and for being a point of reference in healthcare teaching and research. Our healthcare model brings together science technical innovations and humanisation from respect to personal dignity.

Job description

1. Why join us

The Advanced Therapies Platform atSant Joan de Déu Barcelona Childrens Hospitalis a state-of-the-art infrastructure dedicated to the development and manufacturing of Advanced Therapy Medicinal Products (ATMPs) with a strong focus on pediatric applications.

The Platform spans over1280 m² including ATMP research and development areas GMP manufacturing and cryopreservation facilities and administrative spaces. The manufacturing area includesfour certified GMP cleanroomsand is focused on the production of cell and gene therapies such as CAR-T and dendritic cells as well as the manufacturing oflentiviral vectors (LVV). The Platform collaborates with both academic institutions and pharmaceutical companies at national and international levels.

The Advanced Therapies Platform is part of leading national and international networks specialized in ATMPs and drives cutting-edge research and manufacturing projects. It brings together amultidisciplinary teamof biologists biotechnologists physicians pharmacists technicians and researchers ensuring a highly stimulating comprehensive and collaborative work environment.

Our mission is to transform research intoreal therapies that save lives. If you are looking for a role where your technical expertise has a direct and tangible impact on patient health this is your place.

1. Position Mission

To lead and coordinate GMP manufacturing activities for advanced therapies and lentiviral vectors ensuring regulatory compliance product quality and operational efficiency and contributing to patient access to innovative therapies particularly in the pediatric setting.

The Production Manager will oversee a team of production technicians working in close collaboration withQuality Assurance (QA)andQuality Control (QC)departments and in coordination with Platform leadership to ensure proper execution of operations within the established regulatory and organizational framework.

1. Key Responsibilities

Production Management

• Supervise and execute manufacturing activities in classified cleanrooms (Grade B/C depending on the process).
• Plan and coordinate production campaigns for cell and gene therapies (including CAR-T) and other ATMPs.
• Plan and coordinate lentiviral vector (LVV) production campaigns.
• Oversee and execute technology transfer processes from external entities (academic or industrial) into the GMP environment.
• Lead the development and implementation of new manufacturing processes.
• Work closely with QC QA and the Qualified Person (QP) to ensure operational continuity.

Quality and Regulatory Compliance

• Ensure proper execution and review of batch records and all associated GMP documentation.
• Proactively manage deviations out-of-specification results (OOS) CAPAs and change controls.
• Actively participate in regulatory audits and inspections (e.g. AEMPS EMA FDA).
• Ensure qualification training and continuous development of production staff.

Continuous Improvement and Innovation

• Lead technology transfer from R&D laboratories to GMP production.
• Implement continuous improvement initiatives to optimize efficiency and reduce risks and costs.
• Evaluate and integrate new technologies including automation and closed systems (e.g. CliniMACS Prodigy).

Team Leadership

• Lead motivate and develop the production technical team.
• Set clear objectives evaluate performance and foster professional development.
• Act as a key interface between the Platform and external partners for manufacturing and technology transfer activities.

Cross-functional Collaboration

• Collaborate closely with clinical regulatory pharmaceutical and research teams as well as external partners (hospitals biotech companies etc.).

DAY SCHEDULE AND CONTRACT:

• The working day will be at 100% from Monday to Friday with midday break.
• Hours: 8:00h to 16:44h. Performance of on-call and on-site duty.
• Permanent contract.

Requirements

Mandatory Requirements

• Education:Degree in Pharmacy Biology Biotechnology or a related scientific discipline.
• Professional Experience:Proven experience in GMP manufacturing environments.
• Technical Expertise:Hands-on experience in cell and/or gene therapy production including work in classified cleanrooms.
• Team Management:Previous experience leading and managing technical teams.
• Regulatory Knowledge:Strong knowledge of EU-GMP regulations (EudraLex Volume 4) and ATMP-specific legislation (Regulation (EC) No 1394/2007).
• Languages:Fluent Spanish. English level B2C1 (required for technical documentation audits and international collaboration).

Preferred Qualifications

• Additional Education:PhD or postgraduate specialization in Advanced Therapies (ATMPs).
• Specific Experience:Direct experience in CAR-T and/or other ATMP manufacturing and/or viral vector (LVV) production.
• Inspections:Experience in regulatory inspections (AEMPS EMA etc.).
• Technology:Practical knowledge of automated cell processing systems (e.g. CliniMACS Prodigy).
• Environment:Experience in technology transfer and/or work in hospital or academic settings.
• R&D:Experience in leading or participating in ATMP research and development projects.

1. Benefits

• Professional Development:Continuous training opportunities and participation in national and international conferences.
• Meaningful Impact:Direct involvement in cutting-edge projects with immediate clinical application.
• Contract: Permanent.
• Flexible Compensation Plan.

DOCUMENTS TO SUBMIT:

To apply for this job and attach your resume click the Apply button on this screen.

The application period is 30 calendar days from the date of publication of this announcement.

We encourage you to focus your application on your experience and skills. It is not necessary to include a photograph gender or age.

Esplugues de Llobregat April 22 2026