Senior OT Infrastructure Engineer

Senior OT Infrastructure Engineer

Location: Monksland Athlone

37.5 per week (MonFri 09:0017:00 flexible)

Competitive salary and benefits

Opening date: 14/04/2026

Closing date: midnight 20/04/2026

The Senior OT Infrastructure Engineer is a key member of the AAMF Manufacturing Systems team responsible for the design reliability cybersecurity and lifecycle management of GMPcritical OT infrastructure. This includes DCS/PLC/SCADA systems data historians servers and networks that underpin drug product manufacturing.

Working at the interface of IT and Automation the role ensures systems remain highly available secure and compliant while enabling digitalisation analytics and AI initiatives aligned with Industry 4.0 and site strategy.

Accountabilities:

Own reliability availability and performance of GMPcritical OT systems and networks

Maintain OT systems in a validated auditready state (cGMP GAMP 21 CFR Part 11 data integrity)

Plan and implement patching upgrades preventative maintenance and obsolescence strategies

Lead OT cybersecurity controls including network segmentation vulnerability management and incident response

Govern change control risk assessments IQ/OQ/PQ support and deviation investigations

Manage backups disaster recovery redundancy and restore testing

Drive OT upgrade projects from design through validation and cutover

Manage thirdparty vendors and system integrators

Support AVEVA PI data ingestion data quality and infrastructure readiness for analytics and AI solutions

Collaborate with Automation Manufacturing QA Global Security and IT

Support training standardisation and OT maturity across the manufacturing network

Essential Skills & Experience:

• Proven experience in OT / industrial IT within GMP manufacturing environments
• Handson experience with DCS/PLC/SCADA systems (DeltaV strongly preferred)
• Strong experience with AVEVA / OSIsoft PI and SQL Server in validated environments
• Expertise in OT infrastructure (VMware/HyperV Windows Server backups endpoint hardening)
• Industrial networking and protocols (VLANs firewalls OPC/OPC UA Industrial Ethernet)
• OT cybersecurity implementation and vulnerability management
• Strong knowledge of cGMP GAMP 5 change control and validation
• Proven ability to lead complex OT projects and manage vendors
• Excellent communication and technical leadership skills

Desirable Skills & Experience:

• Degree in Engineering Computer Science or similar
• Experience with Siemens Rockwell BMS/HVAC Kepware or AVEVA platforms
• Scripting (PowerShell) and cloud/analytics integration exposure
• OT/IT certifications (ISA/IEC 62443 GICSP VMware Microsoft)

At AstraZenecas Alexion Rare Disease unit work connects directly to people living with rare and devastating conditions turning advanced science into meaningful impact every day. Colleagues collaborate in an open inclusive environment that blends the agility of a biotech with the reach and resources of a global biopharma enabling bold ideas in digitalisation AI and advanced manufacturing to move quickly from concept to reality. Learning is continuous with opportunities to grow skills broaden experience and contribute to pioneering therapies that address areas of high unmet need while staying grounded in integrity transparency and ethical decision-making.

If this opportunity resonates apply now to help shape the future of manufacturing for people living with rare diseases!

Date Posted

Closing Date