Researcher in Immunotherapy of cancer

Chimeric Antigen Receptor (CAR) therapies have demonstrated remarkable clinical efficacy in otherwise fatal cancers; however their therapeutic success has so far been limited to a narrow range of tumour types. K101CAR which targets the MUC16 antigen represents a promising strategy for the treatment of pancreatic cancer.

The aim of this project is to enhance the expression and performance of K101CAR using a fourthgeneration CAR design. By implementing a virusfree transfection system the project seeks to generate a product of superior quality improved safety and greater translational potential.

The candidate must hold a PhD degree in a relevant scientific field and already have postdoctoral experience in immunology or immunotherapy.
Knowledge and practical experience in all of the following domains are mandatory and must be documented:

• Immune cell culture (PBMC isolation primary Tcell manipulation and functional assays)
• Immunological methods (flow cytometry ELISA)
• Animal experimentation (FELASAC or equivalent certification)

Experience in one or more of the following areas will be considered an advantage:

• Molecular biology (cloning RNA isolation qPCR retro or lentiviral manipulation)
• Cell biology: spheroid or organoid culture or organonachip systems
• CRISPR/Cas9 genome editing
• Immunotherapy: vaccine development BiTEs immune receptors (TCR CAR or others)
• Advanced microscopy (confocal) or livecell imaging

The candidate should be hardworking independent and ambitious. We seek someone mature and responsible capable of driving the project at the bench organizing meetings with partners in 4KAPAI and disseminating results.
We offer a dynamic and modern research environment equipped with stateoftheart instruments and direct access to hospital core facilities. We support personal development and encourage training in relevant areas.

The application (in English) must include:

1. Motivation letter (½ page online): a brief explanation of why we should hire you what you will bring to the lab and your ambitions.
2. List (attachment-1): detailing the mandatory techniques listed above including the lab where each was performed and any related publications. Additional relevant skills may also be included.
3. CV (use the online form) with all relevant information
4. List (attachment-2): publications/patents (title authors journal) with a brief description of your contribution to your top five.
5. Official copies of educational certificates (attachment-3) including grades.

Please respect the requested document lengths and do not use AI. Applications exceeding page limits including unrequested documents or containing AIgenerated material will be disqualified.

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