Senior Scientist, Protein Science & Analytics, Biologics Engineering
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Posted on:
2 days ago
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1 Vacancy
Job Summary
Job Title: Senior Scientist Protein Science & Analytics Biologics Engineering
Location: Cambridge UK
Salary: Competitive with excellent benefits
Introduction to the Role:
Pioneer a new future to meet global healthcare challenges.
Biologics Engineering is responsible for the discovery and optimisation of biological candidate drugs to support all therapy area drug discovery pipelines and for the development of in-house biologics discovery platforms and novel drug modalities to support future drug discovery efforts.
About the Role:
We are seeking a Senior Scientist to providemass spectrometryexpertise in support of biologics drug discovery and technology development across multiple therapy this primarily labbased role you will be reponsible formass spectrometry method developmentand thecharacterisation of novel antigens and biologic molecules collaborating within a multidisciplinary team to deliver highquality data and clear scientific insight. Within Biologics Engineeringanalytical datadrives decisions to ensure our molecules are the right qualitycrossfunctional teamsspark innovation and your expertise will helpaccelerate medicines to patients.
Accountabilities
- Design development and execution of mass spectrometry experiments for biologic drug discovery or technology development projects including intact mass analysis peptide mapping analysis and native MS. Ability to apply knowledge of antibody posttranslational modifications to guide experimental design and data interpretation.
- Background in additional biophysical characterisation techniques including chromatography techniques (HPLC UPLC Ion-Exchange & Reverse-Phase methods) and SEC-MALS.
- Practical experience in Hydrogen Deuterium eXchange -MS (HDX-MS) with expertise in some of its applications: protein folding protein dynamics protein interactions or conformational characterisation studies.
- Knowledge and experience in the operation and maintenance of mass spectrometry instrumentation.
- Ability to effectively analyse analytical data make detailed observations and interpret results while tailoring methods to project needs and solving diverse assay challenges. Understands the implications of the data for the drug discovery process and communicates actionable next steps.
- Strong collaboration and interpersonal skills working within a multi-disciplinary team
- Understands and applies principles theories and techniques used in mass spectrometry for characterisation of proteins.
- Pro-actively contributes to development of new analytical characterisation methods and shows enthusiasm for adopting new technologies and automation
- Prepares high quality documentation including electronic laboratory notebooks contributions to patents and IND reports and conducts work according to current codes of practice (health and safety legislation etc.) and all other relevant internal AstraZeneca standards and external regulations.
- Presents clear and concise findings at internal (intra- and inter-departmental) project team and community of practice meetings.
- Builds and leverages strong working relationships with other departments (e.g. Discovery Sciences and Biopharmaceutical Development) to enable effective collaboration and project milestone delivery.
Essential Requirements
- PhD in life sciences with postdoctoral experience (or equivalent working experience) with proven lab-based experience in mass spectrometry techniques.
- Experience in devising and running mass spectrometry experiments; analysing data using software packages and interpretation of results.
- Familiary with mass spectrometry instrumentation & troubleshooting
- Track record of contributions to technology and process improvements.
- Strong communicator capable of developing good working relationships with individuals across organisational boundaries.
- Experience in working within multi-disciplinary teams.
- Has scientific curiosity and proactively develops knowledge.
- Acts with integrity and does the right thing.
- Attention to detail.
Desirable Requirements
- Experience in other complimentary biophysical or structural biology techniques (i.e SPR NMR cryoEM or others).
- Industry experience working on early-stage antibody drug discovery antibody formats or other novel modalities (i.e multi specific mAbs).
- Familiaraity with Genedata Biologics for molecule registration and data management.
- Experience developing or using bioinformatics workflows and integrated data analysis platforms
- Experience implementing laboratory automation and higherthroughput process improvements to enhance efficiency robustness and reproducibility.
Why AstraZeneca:
AstraZeneca is a science-led global biopharmaceutical company with a focused portfolio in core therapies. At AstraZeneca we turn ideas into life changing medicines. We are committed to improving the health and lives of people across the globe through our research and development platform and a growing late-stage pipeline. Working in over 100 countries we have strength in emerging markets and our medicines are used by millions of patients and clinicians worldwide. Working here means being results-oriented and working together to make the impossible a reality.
Here you will apply cutting-edge biophysics automation and AI-enabled analytics to help transform the future of cancer treatment. We unite decisive science-driven teams who act fast on smart risks speak up and challenge conventionalways guided by evidence. With a deep pipeline and unparalleled data you will collaborate with diverse experts learn across disciplines and see your work directly influence how new medicines move forward. We value kindness alongside ambition and we bring unexpected teams together to unleash bold thinking that turns complex problems into meaningful progress for patients.
Where can I find out more
Our Social Media
Follow AstraZeneca on LinkedIn AstraZeneca on Facebook AstraZeneca on Instagram youre ready to turn high-throughput developability data into better biologics with real patient impact step into this Cambridge role and show us how you will elevate our science and speed our decisions!
Date Posted
01-Apr-2026Closing Date
09-Apr-2026Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion starting with our recruitment process. We welcome and consider applications from all qualified candidates regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations please complete the section in the application form.Required Experience:
Senior IC
Key Skills
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more
