Principal Scientist, Chemical Biology Discovery Chemistry
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Posted on:
Yesterday
Vacancies:
1 Vacancy
Job Summary
At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at .
As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.
Job Function:
Discovery & Pre-Clinical/Clinical DevelopmentJob Sub Function:
Chemical ResearchJob Category:
Scientific/TechnologyAll Job Posting Locations:
Beerse Antwerp Belgium Toledo SpainJob Description:
About Innovative Medicine
Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.
Please note that this role is available across multiple countries and may be posted under different requisition numbers to comply with local requirements. While you are welcome to apply to any or all of the postings we recommend focusing on the specific country(s) that align with your preferred location(s):
United States - Requisition Number: R-064523
Remember whether you apply to one or all of these requisition numbers your applications will be considered as a single submission.
We are searching for the best talent for a Principal Scientist Chemical Biology - Discovery Chemistry to be located in Beerse Belgium or Toledo Spain.
Purpose: Discovery Chemistry is an integral and growing part of the Innovative Medicine Therapeutic Discovery (TD) organization which is committed to the delivery of high-quality drug candidates in partnership with all six Therapeutic Area (TA) discovery organizations. The Discovery Product Development and Supply (DPDS) mission requires deep scientific expertise in multiple fields including chemistry cellular and molecular pharmacology enzymology and screening technologies coupled with an ability to work collaboratively with internal and external organizations including the discovery facing development teams Discovery Product Research (DPR) and Developability.
We are seeking an outstanding highly skilled and motivated chemist with excellent organic synthesis and chemical biology expertise to lead and manage our internal chemical biology efforts toward delivering high quality hits leads and candidates to Johnson & Johnsons discovery pipeline within our Disease and Pathway Area Stronghold (DAS and PAS) strategy.
The successful individual will be responsible for developing chemical probes and tool compounds to enable biological and mechanistic characterization of novel hits/hit series emerging from high-throughput screens and progressing them through stage-gates. They will be part of our Chemical Biology matrix team and will collaborate heavily with Chemoproteomics and High-Throughput Screening partners to deliver robust chemical biology data packages to discovery programs across Therapeutic Areas.
You will be responsible for:
- Driving and directing chemical biology functions for drug discovery projects working in concert with partners in medicinal chemistry chemoproteomics disease area biology and other key functions.
- Independently designing and synthesizing chemical biology toolsincluding photoaffinity and photocatalytic proximity labeling probestoward various applications as well as supervising and directing synthetic chemistry activities at contract research organizations (CROs).
- Forging a robust relationship with Discovery Technologies & Molecular Pharmacology (DTMP) Chemoproteomics team to design propose and implement chem bio strategies and workstreams to best align with Therapeutics Discovery overall goals.
- Generating novel testable hypotheses to enable clear decision making.
- Presenting data and reports on project status at individual group and departmental meetings.
- Maintaining a significant level of productivity in the laboratory setting.
- Maintaining a healthy publication record in scientific journals and present findings at key conferences.
Qualifications / Requirements:
Education:
- A PhD in Organic Chemistry Medicinal Chemistry or Chemical Biology is required.
Experience and Skills:
Required:
- 5 years of post-PhD experience in Chemical Biology is required.
- Experience in Structure-Activity Relationship (SAR)-driven design and synthesis of small molecules with proven track record of delivering on high quality chemical biology probes and tool compounds with various applications is required.
- Solid understanding of chemical biology and chemoproteomics methods is required including activity-based protein profiling (ABPP) photoaffinity labeling affinity chromatography and cellular thermal shift assay (CETSA).
- Demonstrated application of chemical biology toward addressing any of the following is required: target identification from phenotypic screens target engagement in cells or lysate covalent inhibitor selectivity profiling binding site identification and small -molecule mechanism of action (MOA) elucidation.
- Strong track record of scientific contributions including peer-reviewed first-author publications and presentations at major conferences is required.
- Being abreast of the latest advances in synthetic chemistry and chemical biology is required.
- Ability to succeed within a matrix environment is required.
Preferred:
- Biopharmaceutical industry experience is preferred.
- Working understanding of targeted protein degradation strategies is desirable.
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Required Skills:
Preferred Skills:
Chemistry Collaborating Critical Thinking Drug Discovery Development Equipment Maintenance Industry Analysis Innovation Interdisciplinary Work Organizing Pharmaceutical Trends Pharmacology Quantitative Research Research Ethics Scientific Research Strategic Change Technical Credibility Use of Laboratory EquipmentRequired Experience:
Staff IC
Key Skills
About Company
About Johnson & Johnson A t Johnson & Johnson, we believe good health is the foundation of vibrant lives, thriving communities and forward progress. That’s why for more than 130 years, we have aimed to keep people well at every age and every stage of life. Today, as the world’s larges ... View more
