Senior Scientist Discovery Immunology

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at .

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Job Sub Function:

Job Category:

All Job Posting Locations:

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at Immunology

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

We are searching for the best talent for a Senior Scientist position based in Spring House PA

Position Overview:

This candidate will conduct research directed towards elucidating the protective and pathologic roles of immune cell populations in tissues in health and disease identifying potential pathways for therapeutic intervention and designing and executing in vitro target validation studies.

We are seeking a Senior Scientist to join the Immunology Discovery group. The candidate is expected to design/execute fit-for-purpose experimental plans partnering closely with project team members involved in therapeutics discovery pharmacology and data science. The successful candidate will generate robust reproducible datasets and clear mechanistic narratives to support decision-making at key governance milestones.

Key Responsibilities:

• Design perform and interpret in vitro experiments to support target validation and mechanism of action studies
• Employ pharmacological and genetic (CRISPRi CRISPRa) methods to interrogate activation and/or suppression of specific targets and pathways-of-interest
• Employ in silico approaches to interrogate multi-omic datasets to identify key molecular features and cellular mechanisms and pathways regulating stromal cell activity in disease
• Document research in internal discovery reports manuscripts for external publication and other formats as required
• Present research at internal meetings and external scientific forums
• Work closely with colleagues from partner organizations to enable and/or support research activities
• Work with leadership to establish and maintain involvement in any external collaborations required to support research goals

Requirements:

• PhD in Immunology pharmacology or a related field with 3-5 years of post-doctoral experience and a strong publication record
• Experience with in vitro cell culture particularly with adherent structural cell types (ex. fibroblasts epithelium)
• Experience with in vivo techniques (ex. rodent handling dosing of therapeutic molecules tissue harvesting) is advantageous
• Experience with standard methods for examination of gene and protein expression including quantitative PCR ELISA- and flow cytometry-based methods
• Experience with bioinformatics tools for analysis of differential gene expression in RNA seq datasets is preferred
• Strong oral written and fit-for-purpose communication skills
• Excellent interpersonal & collaborative skills with an ability to operate as part of a team in highly interdependent environment.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via . Internal employees contact AskGS to be directed to your accommodation resource.

#LI-Onsite

Required Skills:

Preferred Skills: