Senior Scientist II Translational Pathologist

MacroGenics

Job Location:

Rockville, MD - USA

Monthly Salary: $ 126200 - 192500

Posted on: 30+ days ago

Vacancies: 1 Vacancy

Job Summary

Summary of Position

The Senior Scientist II - Translational Pathologist will support tissue-based pathology activities across MacroGenics antibody-drug conjugate (ADC) and immunotherapy programs from discovery through IND-enabling studies and early clinical development. This role is responsible for execution of day-to-day histopathologic and biomarker pathology activities including slide review assay support digital pathology analysis and coordination with external CROs.

The position will work closely with the Senior Director of Pathology and cross-functional team members to deliver high-quality pathology data that informs target selection translational strategy safety assessment and development decisions. Scientific and regulatory accountability remains with senior pathology leadership.

Responsibilities and Job Duties

Preclinical & Translational Pathology

Perform necropsy and primary histopathologic assessment of tissues from in vivo pharmacology studies including H&E IHC and multiplex immunofluorescence.
Conduct first-pass assessment of target expression on-target/off-tumor findings ADC payload-related tissue injury and tumor-immune microenvironment features relevant to immunotherapy programs.
Prepare draft pathology interpretations figures and written summaries for internal review and program discussions.

Biomarker & Assay Support

Execute pathology components of translational biomarker strategies as defined by senior Pathology and Translational Medicine leadership.
Support development optimization and validation of single plex IHC and multiplex IHC and IF assays.
Perform tissue annotation and support development and optimization of digital pathology and image analysis algorithms under the guidance of the Senior Director of Pathology.
Contribute pathology data and figures to internal reports study summaries and regulatory-supporting documentation.
Coordinate biomarker assay development and validation with CROs.

Documentation & Data Stewardship

Draft pathology sections for study reports slide decks and internal presentations.
Maintain pathology image libraries annotations and reference materials.
Support development and maintenance of pathology-related SOPs templates and best practices.

Cross-Functional Collaboration

Present pathology findings in internal project team meetings.
Escalate and communicate complex findings safety signals or interpretation questions to the Translational Medicine leadership.

Minimum Qualifications

Education & Experience

MD DVM or PhD with formal training in pathology histopathology or a closely related discipline.
35 years of experience in biomarker target validation translational research biotechnology pharmaceutical or CRO environments.

Skills & Abilities

Hands-on experience with histopathologic and immunohistochemical tissue evaluation.
Excellent pathology diagnostic skills.
Skilled in mIF development validation and spatial analysis.
Experience with digital pathology and image analysis platforms (e.g. HALO QuPath).
Strong scientific writing and communication skills.

Preferred Qualifications

MD/DVM strongly preferred.
Experience supporting ADC immuno-oncology or T-cell engager programs.
Experience working with AI/ML algorithms for digital pathology analysis.
Exposure to GLP toxicology studies and nonclinical safety assessments.
Experience working with external CROs.

Additional Information

The annual rate of pay for the Senior Scientist II position ranges from $00. This role is eligible for the Companys discretionary bonus and discretionary equity incentives. Eligible employees may participate in the Companys benefits programs including medical / dental / vision / prescription coverage employee wellness resources 401(k) plan with employer match access to an Employee Stock Purchase Plan (ESPP) paid time off & paid parental leave benefits and disability benefits.

The annual pay rate range is described in good faith and the Company believes is the range of possible compensation for this role at the time of this posting depending on the candidates experience qualifications geographic location and other factors permitted by law. The Company may ultimately pay more or less than the posted range and this range may be modified in the future. No amount is considered to be wages or compensation until such amount is earned vested and determinable under the terms and conditions of the applicable policies and plans. The amount and availability of any bonus commission benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole discretion unless and until paid and may be modified at the Companys sole discretion consistent with the law.

Statement

MacroGenics is proud to be an equal opportunity employer. Employment selection and related decisions are made without regard to race color national origin sex gender identity sexual orientation religion age disability protected veteran status or any other characteristic protected by federal state or local law. We are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the employment process please email or call and/or 711 for TTD/TTY service.

Equal Opportunity Employer/Veterans/Disabled

We do notaccept non-solicited resumes or candidate submittals from search/recruiting agencies.

Required Experience:

Senior IC

Summary of PositionThe Senior Scientist II - Translational Pathologist will support tissue-based pathology activities across MacroGenics antibody-drug conjugate (ADC) and immunotherapy programs from discovery through IND-enabling studies and early clinical development. This role is responsible for e...