Senior Scientist II Translational Pathologist
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Job Location:
Rockville, MD - USA
Monthly Salary:
Not Disclosed
Posted on:
2 days ago
Vacancies:
1 Vacancy
Job Summary
Summary of Position
The Senior Scientist II - Translational Pathologist will support tissue-based pathology activities across MacroGenics antibody-drug conjugate (ADC) and immunotherapy programs from discovery through IND-enabling studies and early clinical development. This role is responsible for execution of day-to-day histopathologic and biomarker pathology activities including slide review assay support digital pathology analysis and coordination with external CROs.
The position will work closely with the Senior Director of Pathology and cross-functional team members to deliver high-quality pathology data that informs target selection translational strategy safety assessment and development decisions. Scientific and regulatory accountability remains with senior pathology leadership.
Responsibilities and Job Duties
Preclinical & Translational Pathology
- Perform necropsy and primary histopathologic assessment of tissues from in vivo pharmacology studies including H&E IHC and multiplex immunofluorescence.
- Conduct first-pass assessment of target expression on-target/off-tumor findings ADC payload-related tissue injury and tumor-immune microenvironment features relevant to immunotherapy programs.
- Prepare draft pathology interpretations figures and written summaries for internal review and program discussions.
Biomarker & Assay Support
- Execute pathology components of translational biomarker strategies as defined by senior Pathology and Translational Medicine leadership.
- Support development optimization and validation of single plex IHC and multiplex IHC and IF assays.
- Perform tissue annotation and support development and optimization of digital pathology and image analysis algorithms under the guidance of the Senior Director of Pathology.
- Contribute pathology data and figures to internal reports study summaries and regulatory-supporting documentation.
- Coordinate biomarker assay development and validation with CROs.
Documentation & Data Stewardship
- Draft pathology sections for study reports slide decks and internal presentations.
- Maintain pathology image libraries annotations and reference materials.
- Support development and maintenance of pathology-related SOPs templates and best practices.
Cross-Functional Collaboration
- Present pathology findings in internal project team meetings.
- Escalate and communicate complex findings safety signals or interpretation questions to the Translational Medicine leadership.
Minimum Qualifications
Education & Experience
- MD DVM or PhD with formal training in pathology histopathology or a closely related discipline.
- 35 years of experience in biomarker target validation translational research biotechnology pharmaceutical or CRO environments.
Skills & Abilities
- Hands-on experience with histopathologic and immunohistochemical tissue evaluation.
- Excellent pathology diagnostic skills.
- Skilled in mIF development validation and spatial analysis.
- Experience with digital pathology and image analysis platforms (e.g. HALO QuPath).
- Strong scientific writing and communication skills.
Preferred Qualifications
- MD/DVM strongly preferred.
- Experience supporting ADC immuno-oncology or T-cell engager programs.
- Experience working with AI/ML algorithms for digital pathology analysis.
- Exposure to GLP toxicology studies and nonclinical safety assessments.
- Experience working with external CROs.
Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Mammalian Cell Culture
- Biochemistry
- Assays
- Protein Purification
- Research Experience
- Next Generation Sequencing
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
As a biopharmaceutical company, our team of dedicated individuals is focused on discovering and developing innovative antibody-based therapeutics designed to modulate the human immune response for the treatment of cancer. Our core scientific expertise is in the field of protein engine ... View more
