(Senior) Scientist
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Job Location:
Basel - Switzerland
Monthly Salary:
Not Disclosed
Posted on:
4 hours ago
Vacancies:
1 Vacancy
Job Summary
At RhyGaze we are currently seeking a highly skilled motivated and proactive (Senior) Scientist with a background in Ophthalmology Neuroscience Molecular Biology or related fields and strong hands-on experience in cell and molecular biology to join our Discovery Team. The ideal candidate will possess a proven ability to advance complex research programs in fast-paced environments by independently designing executing and troubleshooting experiments.
Tasks
Your profile:
- Committed to excellence and continuous learning
- Results-oriented
- Highly adaptable
- Resilient mindset
- Collaborative team player
- Able to operate under tight deadlines
Responsibilities will involve laboratory-based and operational tasks including:
- Establish and optimize molecular biology assays (nucleic acid isolation PCR including digital and quantitative molecular cloning).
- Handle and experimentally manipulate primary eye cells and cell lines with excellent aseptic technique.
- Assess targeting efficiency of CRISPR/Cas9 assets in vitro and in samples from in vivo studies.
- Use confocal microscopy together with image analysis software (Fiji QuPath Imaris) to examine cells and tissues and perform diverse quantifications.
- Analyze summarize and interpret experimental data.
- Maintain accurate and detailed experimental records in electronic lab notebook.
- Scientific writing and presentation of research plans and results.
- Contribute to the management of suppliers and vendors.
- Contribute to the building of quality systems and experimental protocols.
- Maintain a tidy well-organized and functional lab.
Requirements
- PhD in Ophthalmology Neuroscience Molecular Biology or related field.
- 3 years hands-on experience performing molecular biology assays in an industrial academic or clinical setting.
- Strong technical understanding of and hands-on experience with the CRISPR/Cas9 system.
- Solid knowledge of eye anatomy and gene therapy.
- Demonstrated ability to work independently in a fast-paced environment.
- Ability to interact effectively with cross-functional stakeholders.
- Highly collaborative and self-driven.
- Excellent written and oral communication skills in English.
Additionally desired but not essential qualifications:
- Experience in a biotech start-up environment.
- Experience in the use of lipid nanoparticles.
- Experience with biochemical assays (Western blot Jess).
Benefits
- The opportunity to be part of a groundbreaking start-up with innovative approaches to solving unmet needs ophthalmology using genetic medicines
- A highly dynamic and supportive environment with high visibility and the potential for rapid career progression
- An inclusive and ethical workplace
The position is based in Basel Switzerland. Candidates are expected to be onsite but there is flexibility to work from home occasionally. As part of an international team the working language is English; hence strong written and spoken English skills are essential.
Applicants must hold a valid Swiss work permit for this position.
Key Skills
- Laboratory Experience
- Mammalian Cell Culture
- Biochemistry
- Assays
- Protein Purification
- Research Experience
- Next Generation Sequencing
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
RhyGaze is a biotech company developing transformative gene therapies to restore vision in patients with blindness. Our lead program targets patients with blinding retinal diseases and we are committed to bringing life-changing treatments to those in need.
