Senior Scientist I, Cell Therapy Discovery
Share
Job Location:
Monthly Salary:
Posted on:
9 hours ago
Vacancies:
1 Vacancy
Job Summary
SUMMARY OF THE ROLE
You will own key assays and workflows for CAR design T-cell engineering and in vitro functional characterization.
You will work with project teams to make data-driven decisions to move programs from discovery toward translation.
You will also help shape study plans align internal and external teams and ensure timely delivery of milestones across functions.
ROLE & RESPONSIBILITIES
In vitro discovery: Lead CAR construct design and engineering; characterize activity of engineered cell therapies using human primary cells and functional co-culture assays; develop and optimize assays; preferred flexibility to additionally contribute to in vivo study design and execution in partnership with in vivo pharmacology.
Data and analytics: Apply a rigorous data-driven approach to experimental design mechanism-of-action studies and decision-making; use appropriate analytics and visualization; document work to high standards.
Cross-functional collaboration: Drive alignment with other teams including Pharmacology & Toxicology CMC translational science and clinical.
Team and communication: Present results and recommendations to teams; mentor colleagues and foster a productive lab environment.
REQUIREMENTS
Education: PhD in immunology cell biology or related field; or MS with 23 years demonstrated impact in cell therapy discovery
Skills & Capabilities
Human T-cell isolation (PBMC processing magnetic selection) activation (CD3/CD28 cytokines) and culture.
Lentiviral transduction MOI optimization; electroporation for gene edits.
Flow cytometry panel design compensation/gating; advanced phenotyping including memory exhaustion activation and safety markers.
Functional assays: target killing (luciferase/impedance) cytokines proliferation/persistence serial-kill or rechallenge assays; antigen density titration and specificity testing.
Molecular methods: PCR/qPCR plasmid prep; amplicon NGS prep for edit verification and transgene integrity.
Data & Tools: Proficiency with ELN FlowJo GraphPad; understanding of assay acceptance criteria and basic statistics.
Soft Skills: Strong organization communication troubleshooting and ability to manage multiple concurrent studies while mentoring juniors.
Compliance: Biosafety level 2 practices animal ethics (IACUC) research GxP awareness and data integrity standards.
Preferred Experience:
Experience with armored CARs logic-gated CARs or allogeneic edits. Preferably familiar with AML disease.
Advancing CAR-T candidates through lead optimization to preclinical packages; method transfer and qualification with PD/Analytical.
Scale-up evaluations; familiarity with CQAs and comparability for gene-modified T-cell products.
Date Posted
19-1月-2026Closing Date
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds with as wide a range of perspectives as possible and harnessing industry-leading skills. We believe that the more inclusive we are the better our work will be. We welcome and consider applications to join our team from all qualified candidates regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment) as well as work authorization and employment eligibility verification requirements.
Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Mammalian Cell Culture
- Biochemistry
- Assays
- Protein Purification
- Research Experience
- Next Generation Sequencing
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more
