Scientist, Translational Sciences-Immunology

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About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at Immunology

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at are searching for the best talent for a Scientist Translational Sciences (TS) Immunology Translational Sciences and Medicine (TSM) to be located in San Diego CA.

Translational Sciences and Medicine (TSM) is an integrated group of scientists composed of a clinical Translational Medicine (TM) team which conducts early clinical development and experimental medicine studies and a Translational Sciences (TS) team which uses human based data and tissues to support the end-to-end portfolio. Together the TSM group will provide the key learnings/insights on the next wave of novel therapies for patients. Organizationally TSM serves as a pivotal bridge between Discovery Research and the later phase Clinical Development group. TSM provides the necessary scientific and clinical expertise to advance an industry-leading pipeline of novel mechanism small molecules and biologic agents to address unmet need in immune-mediated diseases.

TS has a broad remit stretching from support of discovery with human data to support target selection through development of novel decision-making biomarkers for early phase clinical trials target-centric indication sequencing and prioritization and biomarker support of regulatory filings. The TS organization accomplishes these goals by integrating expertise in biomarker development disease biology research and in the application of immunology and data science technologies to support drug discovery and development.

This position will reside within the ImmunoDermatology group in the Immunology Translational Sciences department and requires a highly motivated and skilled candidate to assist in the clinical progression of innovative therapies across diseases. The successful candidate will be responsible for conducting in vitro cellular assays and human biospecimen analysis to support immunology portfolio assets. The candidate will also conduct assay optimization and development biomarker discovery and external collaboration biospecimen analysis to further Johnson & Johnson Innovative Medicine leadership in immunodermatology. The candidate will bring an enthusiastic discovery mindset to Translational Sciences.

The Scientist will be designing and conducting translational science research to support the Johnson & Johnson immunology portfolio. The selected candidate will conduct translational research to support clinical biomarker analysis molecular and cellular profiling of therapeutic targets using primary human cells and in vitro cell based functional assays for mechanism of action studies. The person in this role will engage in the planning execution and interpretation of laboratory experiments. S/he will be conducting experiments with limited guidance and will be expected to collaborate with internal and external partners (CROs) on assay development and translational research. The candidate will also evaluate and optimize methods for novel platforms to enable multi-omics analysis of patient derived samples. Further the candidate will operate in a highly collaborative environment and deliver high quality support for key stakeholders such as the Dermatology Disease Area Stronghold (DAS) and the Translational Science and Medicine team.

Responsibilities are as follows:

• Manage process and analyze clinical study samples including minimally invasive skin tissue samples (e.g. tape stripping skin scraping microneedling)
• Isolate and culture immune cells from skin and blood
• Conduct ex vivo experiments and cell-based assays using primary human tissue and immune cells
• Perform protein and RNA extraction from minimally invasive skin samples or skin tissues
• Perform novel assay development and qualification
• Utilize molecular biology techniques including RNA/protein extraction qPCR immunoassays bulk RNAseq and Olink-HT to generate proteomic and transcriptomic data
• Perform and analyze immunohistochemistry (IHC) and immunofluorescence (IF) staining
• Apply HALO-AI or similar platforms for image analysis
• Operate and troubleshoot TECAN automation systems for sample processing
• Execute research activities under limited supervision and provide critical analysis and interpretation of data
• Rigorous and timely data generation for clinical trial samples
• Communicate experimental findings through oral presentations and written reports; maintain accurate and detailed experimental records in accordance with company guidelines
• Contribute to conference posters and peer-reviewed publications
• Collaborate closely with team members and adhere to J&J EHS&S safety standards to maintain a safe and productive work environment

Qualifications:

• Bachelors degree in a scientific discipline with 35 years of relevant experience or Masters degree with at least 1 year of experience in biology immunology or related field
• Strong organizational skills and attention to detail; ability to manage multiple tasks and troubleshoot effectively
• Hands-on experience with mammalian cell culture is required
• Proficiency in molecular biology techniques including DNA/RNA/protein extraction qPCR RNAseq and immunoassays
• Experience with histology IHC/IF staining and analysis spatial transcriptomics and scRNAseq is preferred
• Experience with TECAN automation and HALO-AI image analysis platforms is highly desirable
• Experience handling skin samples including minimally invasive sampling techniques (e.g. tape stripping skin scraping microneedling) is strongly preferred
• Background in inflammation or immunology research is strongly preferred
• Proactive mindset with a strong desire to learn troubleshoot and grow professionally

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

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