School of Medicine Open Rank Neuro-oncology and Neurovascular Research

Job Description
The Department of Neurosurgery in the School of Medicine at the University of Alabama at Birmingham ( UAB ) has very active and well-established programs in both neuro-oncology and cerebrovascular clinical research and we are broadening our laboratory research effort in these areas. We are looking to recruit highly motivated individuals to fill the following 4 open research positions for investigators holding MD PhD or MD/PhD degrees: Tenured Professor level Neuro-oncology Researcher Assistant or Associate Professor level Neuro-oncology Researcher Instructor level Neuro-oncology Researcher to work with Dr. James M. Markert Assistant Associate or Tenured Professor level Cerebrovascular Researcher The tenured and tenure track Neuro-oncology positions are open for broadly based research interests in the field of Neuro-oncology including but not limited to both primary and metastatic adult brain tumors genomics proteomics/kinomics or epigenetics at the single cell level immunobiology of host-tumor interactions and relevant patient-derived models of cancer. Successful applicants for the tenured and tenure-track Neuro-oncology positions will work in partnership with the UAB ONeal Comprehensive Cancer Center Neuro-oncology Program. Added preference will be given to candidates whose research can synergize with existing UAB faculty to enable programmatic research support e.g. multiple (principal) investigator grants. The competitive candidate for the instructor Neuro-oncology position will have a research interest in primary and metastatic adult brain tumors genomics proteomics kinomics and epigenetics tumor immunology and/or relevant patient-derived models of cancer. The major focus of the laboratory is oncolytic viral therapy and immunotherapy of cancers for translational research. Applicants should be comfortable supervising and mentoring research staff students and residents. Common assays in the laboratory include tissue culture viral culture PCR RT- PCR cloning and oncolytic viral construction/engineering ELISA Western blotting Southern blotting mouse surgery and necropsy flow cytometry immunohistochemistry and fluorescence microscopy. The laboratory also requires familiarity with biostatistics and enough familiarity with bioinformatics to be able to either code or work with UAB bioinformatics to perform a variety of clustering algorithms and deconvolution analyses to be performed on pre and post-treatment specimens. The laboratory is moving to a larger involvement in single-cell analyses and spatial transcriptomics and the successful candidate should be prepared to develop knowledge and skills in these areas. Competitive candidates for the cerebrovascular position will have areas of interest that include but are not limited to: protective effects of ischemic preconditioning; endothelial dysfunction in ischemic and hemorrhagic stroke; role of inflammation in stroke mechanisms of angiogenesis and arteriogenesis in chronic ischemia and platelet/surface interaction. The successful applicant will join a productive and collaborative interdisciplinary research team consisting of investigators in the Departments of Neurosurgery Neurology and Radiology at UAB . We will provide ample opportunity for developing independent work with state-of-the-art equipment facilities and analytical methods. Ideally these positions will be filled by candidates devoting their full effort towards research with no clinical duties. Fractional effort towards clinical duties is possible if it meshes with the plans of candidates seeking the tenured and tenure-track positions. The University of Alabama at Birmingham ( UAB ) is a research university and academic health center that discovers teaches and applies knowledge for the intellectual cultural social and economic benefit of Birmingham the state and beyond. UAB is internationally renowned for its intensely collaborative culture that has for more than five decades produced breakthroughs in education health care research and service. UAB was ranked #1 in the United States and in the top 10 worldwide in the Times Higher Education World University Rankings 2018 Young University Rankings. UAB Medicine is the third largest public academic medical center in the country with more than 1900 beds and almost 18000 employees. UAB Hospital is the centerpiece of the UAB Health System and is the teaching hospital for the UAB School of Medicine. Situated among major research centers and clinics UAB Hospital provides patients with a complete range of primary and specialty care services as well as the most up-to-date treatments and innovations in health addition to UAB Hospital UAB Medicine includes The Kirklin Clinicof UAB Hospital UAB Callahan Eye Hospital as well as several primary and specialty care clinics a dozen member and affiliate hospitals within Alabama more than 10 cancer associates in the Southeast and the Viva Health HMO . Located in the heart of the Southeast Birmingham is a short drive from Atlanta Nashville Chattanooga New Orleans Memphis and Gulf Coast beaches. Some of the most beautiful suburbs in the United States surround the city. With its picturesque surroundings Birmingham has been recognized as an All American City one of the top ten American cities to live and work and one of the top ten entrepreneurial and job growth hot spots in America. The combination of pleasant weather geography diverse culture activities and lifestyle make this city a wonderful place to live raise a family and practice medicine. For additional information about our department please visit our website at Interested candidates should apply here: by submitting an online application to include a cover letter curriculum vitae and the names of three references. Evaluation of applications will occur as they are received and will continue until the position is filled.

Required Qualifications
Applicants must have an MD PhD or MD/PhD.

Preferred Qualifications
The ideal candidate is an individual with a successful record of external awards publications and a productive lab.