Director, Scientific Operations

About Glyphic:

At Glyphic Biotechnologies we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.

What we are looking for in you

Glyphic is seeking a scientifically rigorous pragmatic and execution-driven leader for a Director of Scientific Operations reporting to the VP of R&D.

The Director of Scientific Operations will own the preparation stabilization and management of evaluation-grade reagents and scientific operations that enable reliable execution of our single-molecule protein sequencing platform. This role works closely with the Director of Chemistry and the Director of Assay Development to translate novel chemical components and reagents into stockable assay-ready units and to collaboratively understand which reagent attributes are most important for assay performance. This is a hands-on leadership role focused on scientific judgment speed and reproducibility in an early-stage R&D environment. Characterization is intentionally fit-for-purpose and evolves alongside assay understanding.

The ideal candidate brings strong operational and scientific judgment clearly distinguishing which reagent attributes matterand which do notfor assay performance while building fit-for-purpose operational frameworks that enable chemistry inventions to be translated into usable reproducible reagents without unnecessary delay or over-characterization.

This role offers a unique opportunity to define and lead scientific operations at a formative stage ensuring reagent knowledge operational infrastructure and assay understanding evolve in lockstep to support the companys next-generation protein sequencing platform.

This is a full-time exempt in-person position with work conducted at our Berkeley CA location.

What youll do

Reagent Preparation & Stocking

• Prepare formulate stabilize and stock evaluationgrade reagents and buffers required for sequencing assays
• Establish storage conditions handling practices and refresh strategies that preserve assayrelevant performance
• Design and run fitforpurpose stability studies to understand how reagents change over time and under different conditions
• Produce and manage reagent and assayready consumable inventories sufficient to support ongoing experiments demos and early evaluations

Collaborative Characterization & Understanding

• Work with Chemistry and Assay teams to identify which reagent attributes matter most for assay performance (e.g. purity activity labeling efficiency degradation modes)
• Perform and coordinate targeted hypothesisdriven characterization to inform assay interpretation and reagent handling
• Translate experimental observations into practical guidance for reagent preparation storage and use
• Avoid premature or exhaustive characterization that does not inform assay performance

CrossFunctional Enablement

• Partner closely with the Director of Chemistry to understand chemical design intent and expected behavior
• Partner closely with the Director of Assay Development to ensure reagents meet assay needs and constraints
• Translate chemistry prototypes into repeatable reproducible reagent preparation workflows
• Identify sources of reagent variability and drive scientific rootcause analysis in collaboration with chemistry and assay teams

Infrastructure Facilities & Process

• Develop lightweight documentation for reagent preparation stabilization storage and usage; translate R&D protocols into fit-for-purpose SOPs as needed
• Build and maintain lab infrastructure required for reagent preparation and storage
• Oversee facilities operations as they relate to R&D serving as the connective tissue between scientific operations and facilities
• Negotiate terms and manage relationships with vendors and service providers; ensure consumables equipment lab spaces and utilities support evolving R&D needs
• Serve as the scientific owner for reagent readiness prior to any future manufacturing transition
• Ensure equipment functionality inventory and supply management safety compliance and other logistical functions of a research laboratory

Team & Lab Operations

• Lead and mentor a small team (approximately 2 people) supporting reagent preparation and general lab stocking
• Oversee daytoday lab readiness including consumables buffers and shared reagent availability
• Establish lightweight processes to keep the lab running smoothly without overengineering

What you need

:

• BS/MS degree in Chemistry Chemical Biology Biochemistry Engineering or a related discipline
• 710 years of relevant industry experience supporting R&D teams in scientific operations
• Proven experience managing reagent inventory forecasting demand and preventing stock-outs for active R&D programs
• Deep hands-on experience with reagent preparation formulation stabilization and fit-for-purpose characterization including translating R&D protocols into usable SOPs
• Familiarity with sequencing or broader omics workflows including custom reagents consumables and specialized equipment
• Demonstrated people-leadership experience including supervising staff and reporting forecasts plans and risks to management
• Strong negotiation skills with external vendors including securing favorable contract terms pricing and supply agreements
• Experience collaborating with procurement and accounting functions (e.g. forecasting inputs hand-offs to AP)
• Excellent cross-functional communication skills and comfort coordinating across Chemistry Assay Development Operations and Facilities

Nice to have:

• Demonstrated ability to proactively identify and resolve emerging scientific or operational issues before they impact assay execution or timelines
• Comfort operating in early-stage environments with minimal structure and evolving priorities

Were looking for teammates with:

• Excellent interpersonal skills capable of building strong relationships and communicating effectively with stakeholders at all levels.
• High emotional and analytical intelligence able to navigate complex team dynamics partnerships and challenges with creativity and logic.
• Resourceful adaptability operates with urgency remains flexible in evolving environments and thrives in ambiguity.
• Collaborative spirit enjoys working across disciplines and explaining complex concepts to diverse audiences.

What you can expect from this role

Work environment:

• Collaborative culture where your ideas and expertise are valued
• Direct impact on product development and company direction

Professional growth:

• Opportunity to build and scale a high-impact scientific operations function.
• Learn from a diverse team of world-class scientists and engineers

Compensation

Estimated Base Salary $166050 - $201925

This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including experience education skillset and geographic location. This range is for the SF Bay Area California location and may be adjusted to the labor market in other geographic areas.

Benefits and Perks:

• Employee Stock Option Plan
• 100% Health Plan Coverage for Employees & Dependents (Medical Dental & Vision)
• Employer Retirement Contributions to 401(k)
• Generous Paid Time Off
• Paid Maternity and Paternity Leave
• Health & Wellbeing Program
• Office Snacks and Beverages
• Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race color religion national origin age sex marital status ancestry physical or mental disability veteran status gender identity or sexual orientation.