(Associate) Scientist Bioinformatics
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Job Location:
Leiden - Netherlands
Monthly Salary:
Not Disclosed
Posted on:
2 hours ago
Vacancies:
1 Vacancy
Job Summary
ProQR Therapeutics is a NASDAQ-listed biotechnology company headquartered in Leiden the Netherlands with an office in and Cambridge Massachusetts USA. At ProQR we are on a mission to edit RNA treat disease and change lives. A team of 180 enthusiastic ProQRians from all walks of life and more than 30 different nationalities is committed to pioneering transformative RNA therapies to make a difference in the lives of the communities we serve.
Our proprietary Axiomer RNA editing technology platform enables the editing of specific single nucleotides in RNA using the cells own editing machinery. Axiomer RNA editing technology harnesses ADAR (Adenosine Deaminase Acting on RNA) a protein which is present in all human cells to repair G-to-A mutations modulate protein and enable protective mutation functions. Axiomer could potentially yield a new class of innovative medicines and treat currently untreatable diseases. By harnessing the power of RNA editing we aim to create a world where genetics inform your health - but never limit it.
Our R&D department is currently looking for an experienced (Associate) Scientist Bioinformatics (Full-time) to join our team in Leiden.
The (Associate) Scientist Bioinformatics will support the wet-lab scientist with generating insight-driven oligonucleotide design conduct research to devise improved (in silico) oligo design methods to accurately understand their structure interaction with the target and relevant biological properties. Furthermore the candidate will provide technical input for data mining analysis analysis of transcriptomics studies and execution and/or coordination of various bioinformatics projects.
Location: Leiden NL (on-site)
We expect our (Associate) Scientist Bioinformatics to have:
An advanced degree (PhD or equivalent) in bioinformatics or another relevant field preferably related to biochemistry or a MSc degree with relevant work experience (3-4 years) in academia or within the Biotech/Pharmaceutical industry (preferred).
A biochemistry background with a clear focus on nucleic acid and/or protein folding enzymology and thermodynamics (must).
Solid understanding of the physical and biochemical principles underlying molecular interactions relevant to RNA-based therapeutics.
Experience in the field of genetic disorders and/or oligonucleotide-based therapies.
Proficiency in relevant programming languages (e.g. Python R) and Git. (must)
Practical knowledge of transcriptomics data analysis (RNA-seq) differential gene expression and/or RNA isoform analysis.
Experience with good data practice policies and exposure to open-source systems.
Experience with data mining analysis and system scalability is a plus.
Experience with setting up the relevant infrastructure (hardware software and other tools) is a plus.
Skills and competencies that are required for making the difference:
Analytical and accurate
Creative thinker
Flexible and resistant to change
Hands-on mentality
Pro-active attitude
Teamplayer
Patient-oriented attitude
Autonomous and coachable
Able to work in a fast-paced environment
Strong project planning and management skills
Able to prioritize multiple tasks
Critical thinking decision making and problem-solving skills
Excellent communication skills
Pro-active and pragmatic self-starter with a result-oriented mindset
Excellent knowledge of spoken and written English (and Dutch)
A nice person :)
ProQR as an employer
As an employer we value a diverse workforce in which people are encouraged to develop themselves both personally and professionally. We believe that when people are happy energized and supported by an environment in which they can thrive they can achieve extraordinary things. We are committed to ensuring that no employee candidate or job applicant receives less favorable treatment on the grounds of race age disability pregnancy religion gender identity and expression sexual orientation marriage or civil partnership status. At ProQR we want to create an inclusive culture where everyone can be valued for who they are and in which individual differences and contributions in all forms are recognized and valued. We offer an exciting and innovative working environment in a very committed organization with the following benefits:
8% holiday allowance
30 vacation days
An annual performance bonus
Stock options
A premium-free pension plan
A commuting allowance
A subsidized staff restaurant
Unlimited (un)healthy snacks and drinks
Employee events (boot camp Coffee and Collaboration Café and other social events)
We are looking for people who are inspired by our mission to edit RNA treat disease and change lives. Are you up for the challenge
Submit your application via the Apply button below. Please contact Silvia Catellani via if you have any questions.
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Key Skills
- Laboratory Experience
- ELISA
- Immunoassays
- Transfection
- Mammalian Cell Culture
- Suspension Experience
- Biochemistry
- Assays
- cGMP
- Cell Culture
- Molecular Biology
- Flow Cytometry
