Associate Director, Pharmacometrics

The Organization

Whats happening at Entrada Therapeutics Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues resulting in an improved therapeutic index. Through this proprietary versatile and modular approach Entrada is advancing a robust development portfolio of RNA- and protein-based programs for the potential treatment of neuromuscular and ocular diseases among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44 45 50 and 51 skipping amenable. Entrada has partnered to develop a clinical-stage program VX-670 for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

We are looking for someone who is enthusiastic about modeling and the big picture of drug development. You are passionate about joining a growing organization where your knowledge and experience are highly valued. You thrive in a collaborative environment working with others to enhance infrastructure throughout the organization. You follow up and follow through efficiently connecting problems with solutions

The Opportunity

We are seeking a dynamic and motivated Associate Director Pharmacometrics with deep quantitative pharmacology expertise who will report to the Head of Clinical Pharmacology and partner closely across functions within a growing organization. The ideal candidate will have a strong background in the applications of model-based drug development within the biotechnology or pharmaceutical industry. The ideal candidate is passionate about translating science into approved and accessible medicines

Responsibilities

• Use modeling approaches to advance clinical and translational research at Entrada Therapeutics.
• Lead cross-functional teams with scientific acumen to develop and execute pharmacometrics for programs across all phases of drug development.
• Support the development of diverse modeling strategies and execution in collaboration with the Head of Clinical Pharmacology to bring value to the Entrada portfolio.
• Work collaboratively with functional partners including Clinical Development Biostatistics Non-Clinical Product Development Clinical Operations and Regulatory to deliver on both project team and corporate objectives.
• Author regulatory documents including analysis plans study reports population PK reports exposure-response analyses reports and other similar documents.
• Execute pharmacometrics analyses independently to support internal and external decision making and address key drug development questions.
• Integrate pharmacometrics insights into core deliverables supporting drug development milestones and governance or decision boards.
• Monitor work with CROs and other external vendors to ensure compliance with agreed protocols quality standards and timelines.

The Necessities

At Entrada our passion for science our devotion to patients and our values drives ourbehavior:

• Humanity - We genuinely care about patients and about one another.
• Tenacity - We are relentless and persistent in the pursuit of developing therapiesfor patients.
• Creativity - We are creative problem solvers.
• Collaboration - We are more than the sum of our parts.
• Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team you will need to come with:

• Ph.D. or related discipline or Pharm.D. or M.D. with relevant experience.
• 5 years experience with a background in the application of mathematical pharmacokinetics and statistical methods within pharma/biotech industries or drug development.
• Experience using Phoenix WinNonlin R NONMEM MATLAB or other pharmacokinetic and modeling software.
• Strong mathematical model development and analytical skills.
• Proficient documentation and organizational skills as well as proven ability to be self-motivated and able to work independently.
• Excellent communication and presentation skills to efficiently relay information to project teams and other key stakeholders.
• This is a US based remote position with preference given to local New England based candidates. This role will require minimum monthly or quarterly travel to the Entrada Therapeutics Headquarters located in Boston MA.

What We Offer: Meaningful Work Fair Rewards and Real Support

At Entrada Therapeutics we understand that compensation and total rewards are a major consideration when exploring a new opportunity. We believe in transparency and equity and are committed to sharing salary ranges for every position along with insight into our compensation philosophy in accordance with certain state requirements in the United States and fostering a fair and open environment at the onset.

But we also know it is more than just pay. When you join Entrada youll be part of a mission-driven team with access to comprehensive health dental and vision coverage; life and disability insurance; with a 401(k) match. We pride ourselves on offering competitive benefits that empower our employees and reflect the value of their contributions offering paid gender-inclusive parental leave holistic support for your health and well-being education reimbursement discretionary time off and commuting benefits aligned to your working model. If you find yourself working from our office in Bostons Seaport District this puts you steps away from some of the best the city has to offer.

Our approach to compensation is grounded in transparency equity and performance for the unique contributions each person brings. At Entrada we know that meaningful work deserves meaningful reward and we view compensation as one way we show appreciation for the collaboration curiosity and commitment that drive our mission forward.

Kerry Robert SVP of People

The salary for this opportunity ranges from $180000-$236000. The final base compensation offered will depend on several considerations which include but may not be limited to a candidates skills competencies experience and other job-related factors permitted by law. The final salary offered may fall outside of this range. #LI-JF1 #LI-Remote

Equal Opportunity Employer

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race color religion national origin gender sexual orientation gender identity or expression age mental or physical disability and genetic information marital status citizenship status military status protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Privacy Statement

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