Research Associate II The Macosko Lab
Share
Job Location:
Cambridge, MA - USA
Monthly Salary:
Not Disclosed
Posted on:
30+ days ago
Vacancies:
1 Vacancy
Job Summary
General information
Location
Cambridge MA
Ref #
43689
Job Family
Research
Workplace
On-Site
Date published
02/12/2026
Time Type
Full time
Pay Range
$58000.00/yr - $80667.00/yr
Description & Requirements
Description & Requirements
The Macosko Lab within the Broad Institute of MIT & Harvard is looking for anoutstanding Research Associate II to join our team. The mission of this role is to applytransformative spatial transcriptomics technologiesspecifically Slide-tags andSynapse-seqto uncover how cell types are organized and altered in the context ofneurodegenerative and neuropsychiatric diseases.
We are seeking a highly motivated career-oriented Research Associate to support thiseffort by performing cutting-edge molecular genomics experiments on rare and precioushuman brain surgical specimens. The candidate should be able to conduct complexbench experiments with minimal supervision working in a multidisciplinary environmentalongside neuroscientists and computational biologists. This position offers significantopportunities for growth in genomics technology and neuroscience with the chance topresent data at team meetings and contribute to the refinement of experimentalprotocols. Being a member of our team will provide the opportunity for your contributionsto be utilized and recognized across a large and vibrant community of researchers in thefields of genomics and brain disease research. You will be embedded in a highlymultidisciplinary environment working alongside neuroscientists molecular biologistsand computational scientists to generate data that gives an unprecedented look at thehuman brain.
Primary Responsibilities:
Minimum Qualifications:
The Macosko Lab within the Broad Institute of MIT & Harvard is looking for anoutstanding Research Associate II to join our team. The mission of this role is to applytransformative spatial transcriptomics technologiesspecifically Slide-tags andSynapse-seqto uncover how cell types are organized and altered in the context ofneurodegenerative and neuropsychiatric diseases.
We are seeking a highly motivated career-oriented Research Associate to support thiseffort by performing cutting-edge molecular genomics experiments on rare and precioushuman brain surgical specimens. The candidate should be able to conduct complexbench experiments with minimal supervision working in a multidisciplinary environmentalongside neuroscientists and computational biologists. This position offers significantopportunities for growth in genomics technology and neuroscience with the chance topresent data at team meetings and contribute to the refinement of experimentalprotocols. Being a member of our team will provide the opportunity for your contributionsto be utilized and recognized across a large and vibrant community of researchers in thefields of genomics and brain disease research. You will be embedded in a highlymultidisciplinary environment working alongside neuroscientists molecular biologistsand computational scientists to generate data that gives an unprecedented look at thehuman brain.
Primary Responsibilities:
- Execute and refine standard operating procedures for the anatomical verificationand quality control of human postmortem samples to ensure integrity fordownstream genomics assays.
- Execute the production and preparation of barcoding libraries performing routineoptimizations to maintain library complexity and protocol efficiency.
- Perform complex spatial genomics assays to integrate molecular tracing withhigh-resolution gene expression data.
- Maintain rigorous documentation of experimental parameters and samplemetadata within the E-Lab electronic notebook to ensure the reproducibility oflarge-scale spatial and molecular datasets and facilitate seamless integration forcomputational analysis.
- Coordinate lab operations by mentoring junior staff managing specializereagents and ensuring strict adherence to bench research protocols.
- Support various projects across the lab and in major research consortia (such asthe BRAIN Initiative) by preparing technical data summaries figures andmethodology reports for collaborative working groups.
Minimum Qualifications:
- BS degree in cell or molecular biology neuroscience or a related field.
- 3 years of relevant lab experience (or Masters degree and two yearsexperience); prior experience working in genomics is preferred and particularly experience generating single-cell or spatial transcriptomics data is ideal but not required.
- Exceptional initiative strong motivation and a meticulous systematic approachto detail are essential for this role.
- Excellent proficiency in communication organization and time management.
- Proven ability to work effectively both independently and as a collaborative teammember.
- Creative problem-solving skills coupled with the judgment to seek assistancewhen necessary.
- A strong eagerness to acquire new knowledge and a deep commitment toimpacting patient lives by advancing the understanding of psychiatric andneurodegenerative diseases.
The Broad Institute will not offer visa sponsorship for this opportunity.
The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to relevant skills experience education qualifications and other factors permissible by law.
At Broad your base pay is just one part of a comprehensive total rewards package. From day one this role offers a competitive benefits package including medical dental vision life and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program among other Broad benefits.
The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race national origin religion age color sex disability protected veteran status or any other characteristic protected by local state or federal laws rules or regulations.
Should you need a reasonable accommodation to complete the application or interview process please contact for assistance.
Required Experience:
IC
Key Skills
About Company
Broad Institute is a multidisciplinary community of researchers on a mission to improve human health.
