Principal Research Scientist II, Analytical Development
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Job Location:
Worcester, MA - USA
Monthly Salary:
Not Disclosed
Posted on:
9 hours ago
Vacancies:
1 Vacancy
Job Summary
The Opportunity
We seek a Principal Scientist II Analytical Development to join an experienced fast-paced and collaborative team. This position will be primarily responsible for guiding the biophysical analytical strategy and developing novel analytical methods for characterizing AbbVies mRNA-based targeted lipid nanoparticles (tLNPs) pipeline. This role will manage a small team of scientists focused on biophysical methods for characterizing intact tLNPs and the targeting ligands. Working closely with the technology development and research teams this position will guide development of novel characterization methods drive process/product understanding support expansion of the tLNP platform and pipeline and support product investigations.
Responsibilities & Duties:
- Lead strategy for and development of novel biophysical methods to characterize tLNP drug product and protein components including but not limited to LC/CE/MS DLS MALLS Nano flow cytometry mass photometry BLI and plate-based assays
- Design and lead structure-activity relationship and extended characterization studies to improve tLNP function and stability
- Support product characterization for tLNP platform/formulation development and lead candidate selection
- Establish automation/lipid chromohigh throughput (HTP) workflows and in-process analytical methods for routine and non-routine testing of the tLNP pipeline
- Represent functional area in cross-functional pipeline and technology development teams. Effectively communicate complex technical topics to collaborators and management
- Support method transfer and qualifications as needed
- Manage and develop a team of 2-5 scientists
- Draft technical reports and documents as needed
Qualifications :
Qualifications
- Bachelors Degree in Science related field with 16 years of related work; Masters Degree Science or PharmD with 14 years of related work; PhD in Science or related field with 8 years of related work experience
- Four years of experience managing direct reports and/or a functional team
- Degree in Biochemistry Chemistry Bioengineering Chemical Engineering or related field with proven technical and leadership track record developing analytical characterization methods for nanoparticles (e.g. LNPs viral vectors etc) and biologics (e.g. antibodies mRNA etc) is required
- Experience developing analytical methods for nanoparticles (e.g. nano flow cytometry mass photometry NTA AUC etc.) and biologics (e.g. LC CE iCIEF MS MALLS BLI etc) is required
- Experience with method transfer and qualification is preferred
- Strong proficiency authoring and reviewing technical reports
- Familiarity with international regulatory standards and application to phase-appropriate analytical development and strategy is preferred
- Experience designing and executing stability and comparability studies is preferred
- Exceptional communication skills both written and verbal with a demonstrated capacity to thrive in collaborative team-driven environments.
Additional Information :
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
US & Puerto Rico only - to learn more visit & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:
No
Employment Type :
Full-time
Key Skills
- Machine Learning
- Python
- Data Science
- AI
- R
- Research Experience
- Sensors
- Drug Discovery
- Research & Development
- Natural Language Processing
- Data Analysis Skills
- Toxicology Experience
About Company
AbbVie is a global biopharmaceutical company focused on creating medicines and solutions that put impact first for patients, communities, and our world. We aim to address complex health issues and enhance people's lives through our core therapeutic areas: immunology, oncology, neuro ... View more
