Senior Laboratory Research Scientist Genome Editing in Human Stem Cells

Salary for this Role:

From 45700 per annum with benefits subject to skills and experience.

Job Title:

Reports to:

Closing Date:

Job Description:

Senior Laboratory Research Scientist Genome Editing in Human Stem Cells

Contract term: This is a full-time permanent position on Crick terms and conditions of employment.

Salary for this Role: From 45700 with benefits subject to skills and experience

About us

The Francis Crick Institute is Europes largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent diagnose and treat illnesses such as cancer heart disease infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure cutting-edge facilities and a creative and curious culture. Weve removed traditional boundaries of departments divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the Stem Cells and Organoid Platform (SCOP)

The Stem Cells and Organoid Platform (SCOP) at the Francis Crick Institute provides expert support to enable research involving human materials and data while building institutional capability in key areas such as stem cell biology genetic modification and human model systems.

About the role

We are seeking a Senior Laboratory Research Scientist (SLRS) to lead gene editing and stem cell research with SCOP. You will drive innovative genome engineering strategies across research and service projects working at the cutting edge of human model systems.

Partnering closely with GeMS and other STPS you will take scientific ownership of key initiatives build shared capabilities and provide expert training and guidance. This is a highly visible role for an experienced scientist who thrives on hands-on science collaboration and impact.

See the full job description here

What youll be doing

You will be responsible for:

• Leading and delivering SCOP research and service projects owning scientific direction and outcomes.
• Designing and implementing advanced gene editing strategies tailored to project needs.
• Working closely with GeMS and STPs to develop robust innovative genome engineering solutions.
• Establishing shared methods and technologies with group leaders strengthening institute capability.
• Staying at the forefront of CRISPR technologies through active horizon scanning and engagement.
• Training and mentoring researchers in gene editing and stem cell culture best practice.
• Engineering and maintaining high-quality iPSC and ESC lines ensuring reproducibility and QC.
• Supporting effective lab operations including SOPs biosafety resources and equipment.
• Communicating clearly across teams contributing to reports collaboration and supportive research culture.

About you

You will have:

Essential:

• A higher degree (MSc or PhD) in a relevant field with strong research experience in stem cell biology. *
• Hands-on expertise in human pluripotent stem cell culture (iPSC and/or ESC) and core molecular biology techniques. *
• Experience designing and delivering gene editing strategies using CRISPR/Cas9 and related technologies.*
• Strong experimental design troubleshooting and data analysis skills with excellent attention to quality and reproducibility.*
• Proven ability to manage multiple projects work collaboratively and communicate effectively across multidisciplinary teams.

Desirable

• Experience generating modified pluripotent stem cell lines (e.g. knockouts knock-ins conditional alleles).
• Familiarity with advanced culture systems (e.g. organoids assembloids) and/or automation tools.
• Knowledge of genome engineering workflows reprogramming approaches or bioinformatics tools for guide design and analysis.

About Working at the Crick

Our values

Everyone who works at the Crick has a valuable role to play in advancing the Cricks mission and shaping our culture!

• We arebold. We make space for creative dynamic and imaginative ideas and approaches. Were not afraid to do things differently.

• We areopen. Were highly collaborative and interactive and make sure our activities are visible to the outside world.

• We arecollegial. We show respect for one another work cooperatively and support the wider community.

At the Francis Crick Institute we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued respected and empowered to succeed regardless of their background identity or personal circumstances. We actively encourage applications from individuals of all genders ethnicities abilities and experiences. Weare aDisability Confident: Committedemployer andwant to ensure that everyone can apply and be part of our recruitment processes and sowellmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e. would like to apply by phone or post)please email:

Find out more about life at the Crick.

What will you receive

At the Francis Crick Institute we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:

• Visas: Applicants for this role will be eligible for sponsorship to work in the UK

• Generous Leave: 28 days of annual leave plus three additional days over Christmas and bank holidays.

• Pension Scheme: Defined contribution pension with employer contributions of up to 16%.

• Health & Well-being:

• 24/7 GP consultation services.

• Occupational health services and mental health support programs.

• Eye care vouchers and discounted healthcare plans.

• Work-Life Balance:

• Back-up care for dependents.

• Childcare support allowance.

• Annual leave purchase options.
• Crick Networks offering diverse groups support community and inclusive social events.

• Perks:

• Discounted gym memberships bike-to-work scheme and shopping discounts.

• Subsidised on-site restaurant and social spaces for team interaction.
• Career support: Since September 2017 Crick has been a signatory to the Technician Commitment an initiative across the research sector to ensure visibility recognition career development and sustainability for technicians working in higher education and research across all disciplines.

Please note you must meet the essential criteria listed within the Role Profile to have your application reviewed.

We reserve the right to withdraw this advert at any given time due to the number of applications received.