Senior Research Associate III – In Vivo
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Job Location:
Boston, NH - USA
Monthly Salary:
Not Disclosed
Posted on:
10 hours ago
Vacancies:
1 Vacancy
Job Summary
Overview
Monte Rosa Therapeutics is searching for a Sr Research Associate - In Vivo to assist in executing pivotal proof-of-concept studies in pre-clinical models in mice of inflammation immunology and oncology and assist in the cross-functional development of our research strategy. The role involves interacting with team members to design and execute in vivo/ex vivo pharmacology studies aimed at defining the activity and mechanism of action of compounds. This person will work primarily in our Animal Care Facility ideally 10am-6pm to oversee and perform afternoon/evening and weekend dosing of animals as part of study protocols. This role will have the opportunity to expand their skill set at the lab bench by performing a variety of ex vivo/in vitro experiments.
Responsibilities
Perform basic and intermediate veterinary technical tasks in mice independently including the following:
Administration of selected agents by PO IP SC routes.
Blood sampling techniques via multiple routes including submandibular bleed.
Carry out tissue harvests at later time points based on study requirements.
Preparation of compound formulation for in vivo dosing.
Optimize and perform studies to define target biology in mouse models of inflammation oncology and immunity for in vivo in vitro and ex vivo applications.
Maintain accurate laboratory records/notebooks procedures and data summaries.
Perform evening and weekend dosing of animals as part of study protocols.
Conduct health checks to ensure animal welfare and identify any concerns.
Carry out tissue harvests at later time points based on study requirements.
Prepare and perform formulations for dosing studies.
Oversee breeding programs including monitoring litters and documenting outcomes.
Assist with cage changes and husbandry tasks as needed.
Processing time-sensitive biological samples.
Qualifications
- BS/MS in Biology Pharmacology Animal Science or related field with minimum 4 years relevant experience in an industry setting.
- AALAS certification at the ALAT level is preferred. LVT qualification is a plus.
- Ability to work flexible hours including evenings and weekends as needed is a must.
- Prior experience necessary in handling compounds for formulation preparation with a strong emphasis on safety and proficiency in performing necessary calculations.
- Strong experience in animal handling is required including compound administration by multiple routes harvesting tissue and blood samples and performing necropsy techniques. Experience with surgical techniques is a plus.
- Strong organizational skills and attention to detail.
- Experience in culturing mammalian cell lines is advantageous.
- Experience with pharmacodynamics assays of mouse tissue including Western Blotting or JESS ELISA/Mesoscale and flow cytometry is a plus but not required.
- Willingness to learn new benchwork skills includingsample processingandcell culture.
Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Immunoassays
- Mammalian Cell Culture
- PCR
- Biochemistry
- Assays
- Cell Biology
- Research Experience
- Cell Culture
- Molecular Biology
- Flow Cytometry
- Western Blot
About Company
Pioneering Therapies for Cancer and Beyond – Our drug discovery platform is tailored to promote specific protein ubiquitination and subsequent proteasomal degradation of disease-causing, undruggable proteins, in essence leading to pharmacological protein knockout with high efficiency ... View more
