Process Development Senior Associate Drug Substance Technologies Synthetics (DSTS)

Career Category

Job Description

Join Amgens Mission of Serving Patients

At Amgen if you feel like youre part of something bigger its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980 weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology Inflammation General Medicine and Rare Disease we reach millions of patients each year. As a member of the Amgen team youll help make a lasting impact on the lives of patients as we research manufacture and deliver innovative medicines to help people live longer fuller happier lives.

Our award-winning culture is collaborative innovative and science based. If you have a passion for challenges and the opportunities that lay within them youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Process Development Senior Associate - Drug Substance Technologies - Synthetics (DSTS)

What you will do

Lets do this! Lets change the world!

Amgen is currently seeking a talented Process Development Senior Associate to join our Drug Substance Technologies - Synthetics (DSTS) group. Amgens DSTS group within Process Development (PD) is responsible for the invention development and implementation of drug substance manufacturing processes and technologies to advance Amgens exciting portfolio of synthetic and hybrid assets. Senior Associates in our team collaborate with chemists process engineers and attribute scientists to support drug substance manufacturing from early to late-stage development. The successful candidate will be a highly motivated and team-oriented individual with prior lab-based research experience in organic chemistry or biochemistry/chemical biology.

Key Responsibilities:

• Work within a drug substance team comprised of chemists engineers and attribute scientists to solve technical problems

• Contribute to the invention of synthetic routes and development of safe robust and cost-effective processes to manufacture synthetic and hybrid drug substances

• Support cGMP manufacturing and technology transfer to our internal manufacturing facilities and external contract manufacturers

• Support process characterization activities including process understanding and modeling

• Contribute to drug substance development teams by providing experimental results technical updates documentation data interpretation recommendations etc.

• Works regularly with a supervisor to advance projects within required deadlines.

• Work cross-functionally to deliver regulatory documents and support regulatory filings

• Follows good laboratory documentation practices and standard operating procedures

What we expect of you

We are all different yet we all use our unique contributions to serve patients. The dynamic professional we seek is a collaborator with these qualifications.

Basic Qualifications:

• High school diploma / GED and 6 years of Scientific experience OR

• Associates degree and 4 years of Scientific experience OR

• Bachelors degree and 2 years of Scientific experience OR

• Masters degree

Preferred Qualifications:

• M.S. in organic chemistry or biochemistry/chemical biology with a specialization in synthetic/conjugation chemistry synthetic methodology total synthesis peptide/protein chemistry or oligonucleotide chemistry

• Prior experience with ADC development bioconjugation or related modalities

• Proficiency in analytical characterization techniques such as Hydrophobic Interaction Chromatography (HIC)-HPLC Size Exclusion Chromatography (SEC) Liquid ChromatographyMass Spectrometry (LC-MS) Ion-Exchange (IEX) and Reversed Phase (RP)-HPLC.

• Experience working in pharmaceutical industry with expertise in synthetic peptide oligonucleotide and/or antibody drug conjugate process development

• Demonstrated ability to work in a chemistry laboratory with minimal supervision

• Ability to independently collect and interpret analytical results (NMR HPLC MS IR Raman etc)

• Excellent written and verbal communication skills ability to multitask effectively plan and follow through on projects

• Experience working in cross-functional or matrixed teams

• A research summary included with CV is strongly encouraged

What you can expect of us

As we work to develop treatments that take care of others we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills experience and qualifications.

In addition to the base salary Amgen offers a Total Rewards Plan based on eligibility comprising of health and welfare plans for staff and eligible dependents financial plans with opportunities to save towards retirement or other goals work/life balance and career development opportunities that may include:

• A comprehensive employee benefits package including a Retirement and Savings Plan with generous company contributions group medical dental and vision coverage life and disability insurance and flexible spending accounts

• A discretionary annual bonus program or for field sales representatives a sales-based incentive plan

• Stock-based long-term incentives

• Award-winning time-off plans

• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Apply now and make a lasting impact with the Amgen team.

In any materials you submit you may redact or remove age-identifying information such as age date of birth or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world Amgen fosters an inclusive environment of diverse ethical committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race color religion sex sexual orientation gender identity national origin protected veteran status disability status or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process to perform essential job functions and to receive other benefits and privileges of employment. Please contact us to request accommodation.

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