Systems Analyst II, Global Patient Safety, Systems & Analytics

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team you will join other outstanding Revolutionariesin a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We are seeking a skilled safety systems analyst to join our dynamic Global Patient Safety (GPS) department. The Systems Analyst II position supports the configuration maintenance and continuous improvement of the GPS systems and related technologies. This role serves as a key contributor in ensuring data quality system reliability and operational efficiency across pharmacovigilance processes.

The Systems Analyst II collaborates closely with crossfunctional partners vendors and internal GPS stakeholders to troubleshoot issues extract and format data execute configuration updates and support enhancements that enable scalable inspectionready safety operations.

The successful candidate will be a proactive detail oriented team player who exhibits technical proficiency with best-in-class pharmacovigilance systems. The candidate will meet the following requirements:

System Configuration & Administration

• Support system upgrades and ongoing maintenance through the development of system user and functional requirements qualification scripts and other validation deliverables.

• Effectively communicate and coordinate with internal and external stakeholders to gather and implement requirements.

• Execute routine system configuration updates to support evolving safety processes and business requirements.

• Maintain user roles permissions and access controls in alignment with governance standards.

• Support system validation activities including documentation testing and changecontrol processes.

• Troubleshoot system issues and coordinate resolution with internal teams and external vendors.

Data Quality & Reporting Support

• Assist in the extraction of safety data ensuring accurate and timely distribution to key stakeholders.

• Format safety output (line listings tables graphs) to support regulatory reporting and businesspartner inquiries.

• Familiarity with safety dashboards and analytics including operational metrics signal detection analyses and compliance monitoring reports to support operational insights and decisionmaking.

• Facilitate routine dataquality checks to ensure accuracy completeness and regulatory readiness.

• Investigate data discrepancies and partner with stakeholders to resolve root causes.

Operational Support & Collaboration

• Serve as a technical resource for GPS users providing guidance on system functionality and best practices.

• Participate in continuous improvement initiatives through innovative technology solutions and process enhancements.

• Work collaboratively with Safety Operations Safety Science and other departments to ensure pharmacovigilance system compliance and best in class operations.

• Participate in crossfunctional projects involving system enhancements integrations and process improvements.

• Understand integrations between safety systems and upstream/downstream platforms.

• Document system processes and SOP inputs to support operational consistency and compliance.

• Support vendor coordination for issue resolution enhancement requests and release planning.

Compliance & Inspection Readiness

• Assist in the development of safety system training to ensure common understanding of features and functionality as well as Revolution Medicines consistent and proper use of the system.

• Assist in preparing for global inspections by ensuring all processes and trainings reflect global regulatory requirements.

• Ensure system activities align with GxP expectations and internal quality standards.

• Ensure all safety systems and processes comply with global regulatory requirements including FDA EMA PMDA and other relevant authorities.

• Maintain auditready documentation for configuration changes testing and dataquality activities.

• Support inspection and audit requests by preparing data outputs evidence of system validation and responding to technical inquiries.

Required Skills Experience and Education:

• Bachelors degree in a scientific technical or related field required. At least 2 years in drug safety/pharmacovigilance within the pharmaceutical or biotechnology industry regarding pharmacovigilance safety databases safety reporting systems and data analysis tools.

• Handson experience with safety databases and systems (e.g. Safety One Argus Empirica Signal Veeva Safety Docs) or similar regulated systems.

• Proficiency in data tools such as SQL Spotfire Oracle Analytics Server or equivalent.

• Awareness of global pharmacovigilance regulations and guidelines (e.g. FDA EMA ICH).

Core Competencies

• Strong analytical problem-solving and decision-making skills with the ability to interpret complex safety data to make informed decisions.

• Clear and concise communication with technical and nontechnical stakeholders.

• Ability to manage multiple priorities in a fastpaced environment.

• Collaborative mindset with a focus on partnership and service delivery.

• Commitment to quality and compliance in all systemrelated activities.

• Foster a structured and efficient work environment.

• Excellent written and verbal communication skills with the ability to effectively liaise with internal and external stakeholders.

• Proven ability to think strategically drive innovation and implement process improvements.

Preferred Skills:

• Degree in computer science or related field preferred.

• Working knowledge of pharmacovigilance processes including case processing ICSR and aggregate reporting and electronic data exchanges.

• Experience interacting with regulatory agencies and participating in regulatory inspections and audits.

  #LI-Hybrid #LI-SH1