Principal Scientist or Associate Director, Medicinal Chemistry

Job Title: Principal Scientist/Associate Director Medicinal Chemistry

Reports To: Director Chemistry

Location: Shanghai China

About Us:

Structure Therapeutics develops lifechanging medicines for patients using advanced structurebased and computational drug discovery technology. The companys platform combines the latest advancements in visualization of molecular interactions computational chemistry and data integration to design orally available superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinicalstage pipeline of differentiated treatments focused on chronic diseases with high unmet need including cardiovascular metabolic and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

Position Summary:

We are seeking a highly skilled and motivated Medicinal Chemist to join our dynamic drug discovery team. The ideal candidate will have a strong background in organic chemistry medicinal chemistry and drug discovery. The Medicinal Chemist will be responsible for designing and optimizing novel chemical entities with the potential to become therapeutic agents. This role requires a deep understanding of structure-activity relationships (SAR) pharmacokinetics drug metabolism and safety disease biology and biological assays structure-based drug design and CADD tools/methods as well as the ability to work collaboratively with cross-functional teams. Proven experience leading or contributing to innovative small-molecule drug discovery programs from early screening and hit identification through development candidate nomination is preferred. Experience in managing external CRO (Contract Research Organization) teams is required.

Job Responsibilities:

• As a dynamic medicinal chemist drive and direct medicinal chemistry functions for one or more drug discovery projects working in concert with cross functional team members.
• Critically interpret biological and profiling data and apply SAR analysis structure-based design CADD tools and literature knowledge to conceive and execute iterative medicinal chemistry strategies that advance discovery programs and strengthen patent positions.
• Work with other functional units to contribute to the hit identification for targets important to the company; execute hit follow-up/hit expansion and progress confirmed hit compounds to lead series.
• Supervise and direct synthetic chemistry activities at contract research organizations (CROs).
• Serve as a scientific expert in medicinal chemistry with both internal and external partners and provide recommendations regarding new targets and emerging external opportunities.

Qualifications:

The ideal candidate will have a strong synthetic and medicinal chemistry background with relevant experience working in a drug discovery environment:

• PhD in Organic or Medicinal Chemistry or its equivalent and 5-10 years industry experience in small molecule medicinal chemistry.
• Demonstrated advancement of projects through various stages of drug discovery.
• Experience in hit to lead and lead optimization is preferred.
• More than three years of experience in managing CRO teams.
• Proficiency in complex problem-solving and expert knowledge of modern methods of synthetic/medicinal chemistry.
• Familiarity with structure-based drug discovery experience of working closely with computational chemists as part of project team.
• Fluency in spoken and written English to effectively participate in scientific discussions presentations and documentation within global cross-functional teams.
• Track record of scientific contributions including peer reviewed publications patent applications
• Highly motivated open-minded results driven individual with excellent organizational interpersonal and communication skills.

Travel Required: No

Structure Therapeutics Inc. is an Equal-Opportunity Employer.

Structure Therapeutics is committed to fair and equitable compensation practices and we strive to provide employees with total compensation packages that are market competitive. The exact base pay offered for this role will depend on various factors including but not limited to the candidates geography qualifications skills and experience.

At Structure base pay is only one part of your total compensation package. The successful candidate will be eligible for an annual performance incentive bonus new hire equity ongoing performance-based equity and various benefits offerings.

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Required Experience:

Director