PhD in Super-Resolution microscopy of clinical biopsies for precision medicine

Introduction

Are you passionate about microscopy and its potential to transform healthcare We invite applications for a fully funded PhD position on super-resolution microscopy of clinical biopsies for precision medicine within the Nanoscopy for Nanomedicine group in the Biomedical Engineering Department at Eindhoven University of Technology. This project aims to develop and apply advanced super-resolution microscopy methods to address critical challenges in cancer precision diagnostics and therapy.

Job Description

Super-resolution optical imaging has transformed cellular and molecular biology allowing to visualize biological process at the molecular level. However translating these powerful techniques to clinically relevant samples and precision medicine remains a major scientific and technological challenge. This PhD project aims to bridge this gap by developing and applying super-resolution microscopy to study cancer biomarkers at the nanometer and single-molecule level in real patient material.

In this project you will:

• work with cell line models and lung cancer biopsy samples in close collaboration with clinicians at the Catharina Hospital in Eindhoven
• set up and optimize advanced imaging strategies to visualize and quantify cancer-related biomarkers with unprecedented spatial resolution.
• - combine cutting-edge microscopy with quantitative data analysis you will investigate how molecular organization and heterogeneity at the nanoscale relate to targeted drug mechanisms of action and individual patient responses.

Precision medicine-matching each patient with the most effective treatment-remains one of the grand challenges in oncology. Despite the availability of targeted therapies patient responses vary widely and the molecular origins of treatment resistance are often poorly understood. This project addresses this challenge by introducing novel imaging approaches capable of revealing subtle nanoscale differences in biomarker expression and organization that are invisible to conventional techniques. Your research will contribute to a deeper understanding of therapy response and resistance and may lay the groundwork for new diagnostic and stratification tools with direct impact on healthcare.

The project is embedded in the Nanoscopy for Nanomedicine group at Eindhoven University of Technology and builds on the groups strong expertise in super-resolution microscopy and quantitative bioimaging. It is carried out within the framework of the EuroTech University Alliance and involves close collaboration with EPFL (Lausanne Switzerland). A 6-month research secondment at EPFL is planned offering an international research experience and exposure to complementary expertise in advanced microscopy and biomedical imaging.

During this PhD you will be trained in state-of-the-art optical microscopy quantitative image analysis and interdisciplinary research at the interface of physics biology and medicine preparing you for a career in academia industry or clinical technology development.

Job Requirements

• A masters degree (or an equivalent university degree)in biomedical engineering (bio)physics and other life science related disciplines
• A research-oriented attitude.
• Ability to work in an interdisciplinary team and interested in collaborating with industrial partners.
• Motivated to develop your teaching skills and coach students.
• Fluent in spoken and written English (C1 level).
  
  

Conditions of Employment

A meaningful job in a dynamic and ambitious university in an interdisciplinary setting and within an international network. You will work on a beautiful green campus within walking distance of the central train addition we offer you:

• Full-time employment for four years with an intermediate assessment after nine months. You will spend a minimum of 10% of your four-year employment on teaching tasks with a maximum of 15% per year of your employment.
• Salary and benefits (such as a pension scheme paid pregnancy and maternity leave partially paid parental leave) in accordance with the Collective Labour Agreement for Dutch Universities scale P (min. 3059 - max. 3881).
• A year-end bonus of 8.3% and annual vacation pay of 8%.
• High-quality training programs and other support to grow into a self-aware autonomous scientific researcher. At TU/e we challenge you to take charge of your own learning process.
• An excellent technical infrastructure on-campus childrens day care and sports facilities.
• An allowance for commuting working from home and internet costs.
• A Staff Immigration Team and a tax compensation scheme (the 30% facility) for international candidates.

About us

Eindhoven University of Technology is a leading international university within the Brainport region where scientific curiosity meets a hands-on mindset. We work in an open and collaborative way with high-tech industries to tackle complex societal challenges. Our responsible and respectful approach ensures impact today and in the future. TU/e is home to over 13000 students and more than 7000 staff forming a diverse and vibrant academic community.

Information

Do you recognize yourself in this profile and would you like to know more Please contact the hiring managerLorenzo Albertazzi .

Visit our website for more information about the application process or the conditions of employment. You can also contact Sascha Sanchez HR advisor .

Curious to hear more about what its like as a PhD candidate at TU/e Please view the video.

Are you inspired and would like to know more about working at TU/e Please visit our career page.

Application

We invite you to submit a complete application by using the apply button. The application should include a:

• Cover letter in which you describe your motivation and qualifications for the position.
• Curriculum vitae including a list of your publications and the contact information of three references. Kindly note that we may reach out to references at any stage of the recruitment process. We recommend notifying your references upon submitting your application.

Ensure that you submit all the requested application documents. We give priority to complete applications.

We look forward to receiving your application and will screen it as soon as possible. The vacancy will remain open until the position is filled.

Please note

• You can apply online. We will not process applications sent by email and/or post.
• A pre-employment screening (e.g. knowledge security check) can be part of the selection procedure. For more information on the knowledge security check please consult the National Knowledge Security Guidelines.
• Please do not contact us for unsolicited services.