Principal Scientist, Genomic Technologies

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Principal Scientist Genomic Technologies

We are seeking innovative scientists to join our team as a Principal Scientist. Within GSK R&D Translational Sciences (TSci) the Genomic Technologies team integrates deep and broad expertise in computational and statistical methods and techniques to enable best-in-class analytical insight and interpretation of genetics and genomics data impacting GSK R&D portfolio and pipeline decisions.

We value collaborative working and scientific evaluation of different approaches to improving our capabilities in areas of focus for Genomic Technologies including:

• Discovery of new causal gene-phenotype links by advancing methodology for analysis of large-scale biobank individual human genetic data and of GWAS/xQTL summary statistics.
• Identification of causal mechanisms candidate biomarkers disease subtypes and patient subgroups by analysing and integrating genetic multi-omic and phenotypic data from human populations and from genome-scale gene editing perturbation experiments.
• Predictive modelling of presence direction and magnitude of causal gene-phenotype links using genetic and omic data mechanistic annotation inferred causal networks and genome-scale perturbation data.

In this role you will:

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Generate large-scale analysis outputs and/or implement state-of-the-art tools for dynamically analysing interpreting and visualizing genetic and genomic data.
• Evaluate improve test and develop production implementations of best-in-class methods for analysis of genetics and genomics data in collaboration with scientists in Translational Sciences Biostatistics Data Automation and Predictive Sciences or/and AI/ML teams.
• Collaborate with partners across TSci in experimental Target Discovery and in GSK disease area Research Units to influence portfolio and pipeline decisions.
• Stay informed about recent research in the field and considering its potential for application within GSK.
• Contribute to a culture of innovation quality and willingness to learn and improve.

Why you

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• Advanced degree (PhD or equivalent) in a relevant scientific discipline.
• Experience with genetic genomic epigenomic or experimental/functional genomic data and with state-of-the-art methods for data analysis and interpretation.
• Excellent programming skills in R or/and python and application of techniques in reproducible research literate programming FAIR data principles or software development.
• Experience of evaluating improving testing and/or developing methods for analysis and interpretation of large-scale genetics or genomics data.
• Strong communication and team-working skills.

Preferred Qualifications & Skills:

Please note the following skills are not necessary just preferred if you do not have them please still apply:

• Experience with machine learning and/or advanced statistical methods.
• Experience working in multidisciplinary teams on complex and impactful projects.
• Experience with integrating information across multiple genetic genomic epigenomic or experimental/functional genomic data types.
• Experience with analysis of very large datasets using distributed or cloud computing technologies (e.g. SQL PySpark BigQuery Docker Nextflow).

Closing Date for Applications 13th February 2026

Please take a copy of the Job Description as this will not be available post closure of the advert.
When applying for this role please use the cover letter of the online application or your CV to describe how you meet the competencies for this role as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK we have bold ambitions for patients aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines combining our understanding of the immune system with cutting-edge technology to transform peoples fosters a culture ambitious for patients accountable for impact and committed to doing the right thing making sure that we focus our efforts on accelerating significant assets that meet patients needs and have the highest probability of success. Were uniting science technology and talent to get ahead of disease together.

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Why GSK

Uniting science technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade as a successful growing company where people can thrive.

We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.

People and patients around the world count on the medicines and vaccines we make so were committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients accountable for impact and doing the right thing is the foundation for how together we deliver for patients shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race color religion sex (including pregnancy gender identity and sexual orientation) parental status national origin age disability genetic information (including family medical history) military service or any basis prohibited under federal state or local law.

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