Intern- Downstream Process Development

AskBio Inc. a wholly owned and independently operated subsidiary of Bayer AG is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular central nervous system cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure limb-girdle muscular dystrophy multiple system atrophy Parkinsons disease and Pompe disease. AskBios gene therapy platform includes Pro10 an industry-leading proprietary cell line manufacturing process and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park North Carolina and European headquarters in Edinburgh Scotland the company has generated hundreds of proprietary capsids and promoters several of which have entered pre-clinical and clinical testing.

Our vision: Pioneering science to create transformative molecular medicines.

Our mission: Lead innovative science and drive clinical outcomes to transform peoples lives.

Our principles:

• Advance innovative science by pushing boundaries.

• Bring transformative therapeutics to patients in need.

• Provide an environment for employees to reach their fullest potential.

Our values:

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.

• Cultivate Collaboration. Strive to be the best teammate actively listen openly communicate and embrace diverse points of view.

• Embrace Responsibility. We are humbled by the enormity of our hold a relentless commitment to advance science and clinical outcomes for our patients families and caregivers.

• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.

• Act with Uncompromising Integrity. Be honest transparent and committed to doing whats right in every situation. Make clear commitments and follow through.

Position Summary

The Downstream Process Development Intern will help to implement in-process analytical tools for AAV characterization. The project will involve comparing and correlating data generated from different analytical methods as well as streamlining data entry. This will include evaluating different assays used to quantify product titer stability and purity of process and drug substance samples and automating data collection. The intern will also assist in the production of recombinant AAV by learning about and assisting in the execution of various downstream unit operations.

This position is located in RTP NC and will report to a Senior Research Associate Process Development.

Job Responsibilities

• Support the downstream process development team in the execution of experiments and purification of recombinant AAV

• Learn about various downstream unit operations and analytical assays used for product characterization

• Participate in an individual project to implement in-house analytical tools

• Communicate findings with other lab members

• Develop tools to streamline input and analysis of data

• Present results in a final formal presentation to the process development group

Minimum Requirements

• Pursuing at least a BS degree in scientific or engineering related field

• Must be at least a Junior in university at the time of your application

• Basic understanding of downstream purification techniques (e.g. lysis chromatography filtration fill/finish)

• Basic understanding of analytical methods used to characterize AAV (SEC-HPLC ELISA qPCR DLS etc.)

• Proficient with MS Office Suite and ability to learn new platforms quickly (JMP statistical software)

• Strong sense of accountability and ability to prioritize multiple tasks

• Excellent organizational skills and attention to detail

• Proactive and solution-driven mindset

• Strong sense of accountability and ability to prioritize multiple tasks

• Excellent organizational skills and attention to detail

• Flexible and willing to support a variety of tasks for the downstream PD team

• Available to work full-time at the office during the summer months (May-August) at an AskBio office

Preferred Education Experience and Skills

• Students pursuing a Masters degree in a scientific or engineering field are encouraged to apply

• Experience analyzing and interpreting data from assays characterizing biopharmaceutical products.

• Prior internship work or volunteer/extracurricular experience in the biopharma industry

• Prior experience working in a lab environment

• Prior hands-on experience in biomanufacturing

• Advanced experience with Excel/VBA scripting

AskBio Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race color religion gender sexual orientation gender identity national origin age disability veteran status or any other protected status prohibited under Federal State or local laws. All employment decisions are based on valid jobrelated requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website you may request a reasonable accommodation to express interest in a specific opening by calling us at or sending us an email at .

Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio through any medium will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio no fee or payment of any kind will be paid to the agency.