Intern-Biomarkers, Translational Medicine

AskBio Inc. a wholly owned and independently operated subsidiary of Bayer AG is a fully integrated gene therapy company dedicated to developing life-saving medicines and changing lives. The company maintains a portfolio of clinical programs across a range of neuromuscular central nervous system cardiovascular and metabolic disease indications with a clinical-stage pipeline that includes investigational therapeutics for congestive heart failure limb-girdle muscular dystrophy multiple system atrophy Parkinsons disease and Pompe disease. AskBios gene therapy platform includes Pro10 an industry-leading proprietary cell line manufacturing process and an extensive array of capsids and promoters. With global headquarters in Research Triangle Park North Carolina and European headquarters in Edinburgh Scotland the company has generated hundreds of proprietary capsids and promoters several of which have entered pre-clinical and clinical testing.

Our vision: Pioneering science to create transformative molecular medicines.

Our mission: Lead innovative science and drive clinical outcomes to transform peoples lives.

Our principles:

• Advance innovative science by pushing boundaries.

• Bring transformative therapeutics to patients in need.

• Provide an environment for employees to reach their fullest potential.

Our values:

• Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need.

• Cultivate Collaboration. Strive to be the best teammate actively listen openly communicate and embrace diverse points of view.

• Embrace Responsibility. We are humbled by the enormity of our hold a relentless commitment to advance science and clinical outcomes for our patients families and caregivers.

• Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action.

• Act with Uncompromising Integrity. Be honest transparent and committed to doing whats right in every situation. Make clear commitments and follow through.

Position Summary

This Translational Medicine Biomarkers intern will be responsible for supporting ongoing assay development work for our pre/clinical programs in the wet lab setting. The intern will leverage flow cytometry and other ligand-binding assay platforms to support and develop methods in early-stage biomarker discovery.

Beyond wet lab activities interns are expected to research and present a proposal for the use of a surrogate biomarker in the accelerated clinical approval of a gene therapy drug product. This research activity will culminate with a final presentation of the proposal and strategy for biomarker assessment in a theoretical pre/clinical program.

Applicants are expected to have a cursory level of wet lab competency prior to this internship which can be satisfied by previous academic research and/or course lab work. Overall the role is intended to train and prepare undergraduates who aspire to continue their academic careers in graduate/professional school at research universities or aim to enter the industrial research setting postgrad.

The Intern-Biomarkers Translational Medicine is based in RTP NC and will report to the Principal Scientist Flow Cytometry & Biomarker Data Analysis.

Job Responsibilities

• Support ongoing method development work for pre/clinical programs

• Research the FDA Accelerated Approval Program/Pathway

• Review and verify data packages from historical experiments

• Partner with other Translational Medicine functions to meet deadlines

• Observe trained scientists to learn established experimental methods

• Review documents related to regulatory submissions

• Participate in Translational Medicine team meetings and routine activities

• Assist team members with ongoing program-related projects

• Maintain lab compliance through routine cleaning and maintenance procedures

• Communicate research findings in a formal oral/poster presentation setting

• Present summary of accelerated approval biomarker discovery pathway proposal as a terminal activity

Minimum Requirements

• Must be pursuing a Bachelors degree in a biology/chemistry/biochemistry adjacent field

• Previous wet lab experience via academic labs or prior research experience

• Familiarity with Microsoft Office

• Strong sense of accountability and ability to prioritize multiple tasks

• Excellent organizational skills and attention to detail

• Able to analyze and present scientific concepts to peers

• Proactive and solution-driven mindset

• Strong sense of accountability and ability to prioritize multiple tasks

• Flexible and willing to support a variety of tasks for the Translational Medicine team

• Available to work full-time at the office during the summer months (May-August) at an AskBio office

Preferred Education Experience and Skills

• Prior internship work or volunteer/extracurricular experience

AskBio Inc. (AskBio) is an Equal Opportunity Employer and does not discriminate against any employee or applicant for employment because of race color religion gender sexual orientation gender identity national origin age disability veteran status or any other protected status prohibited under Federal State or local laws. All employment decisions are based on valid jobrelated requirements. If you are a qualified individual with a disability or a disabled veteran and are unable or limited in your ability to use or access our website you may request a reasonable accommodation to express interest in a specific opening by calling us at or sending us an email at .

Agencies: Please do not contact any employee at AskBio about this requisition. Any resume submitted by a recruitment agency to any employee at AskBio through any medium will be deemed the sole property of AskBio unless the agency was engaged by AskBio Talent Acquisition team to recruit for that position. All agencies must have a prior executed service agreement with AskBio prior to any search engagement. If a candidate who was submitted outside of the AskBio agency process is hired by AskBio no fee or payment of any kind will be paid to the agency.