Chief Medical Officer

Company Overview

TwoStep Therapeutics is a biotechnology company developing a pipeline built around a unique tumor-targeting polyspecific integrin-binding peptide (PIP) that can selectively bind several targets that are highly expressed on solid tumors. This multi-targeting feature enables the agents broad applicability to a wide range of tumor types and patient populations overcoming the limitations of single-antigen targeting approaches. The company has leveraged this technology to create a pipeline of targeted cancer therapies for cytotoxic drug delivery and radioligand therapy. TwoStep Therapeutics was co-founded by CEO Caitlyn Miller in collaboration with leading academic entrepreneurs at Stanford University including Nobel Laureate Carolyn Bertozzi Jennifer Cochran and Ronald Levy.

For more information visit or download our 2025 scientific poster (linked here).

Position Overview

We are seeking a Chief Medical Officer (CMO) to oversee and advance a differentiated pipeline of targeted drug conjugates and radioligand therapies designed to address high unmet needs across multiple solid tumor indications. The ideal candidate is a proven cross-functional development leader with experience advancing targeted oncology modalities (e.g. ADCs peptide-drug conjugates radioligands) from IND-enabling through late-stage clinical development.

Key Responsibilities

• Lead the overarching clinical development strategy and execution for the pipeline ensuring seamless alignment with corporate goals scientific innovation and long-term patient impact.

• Serve as the primary medical expert for novel therapeutics to deliver rigorous high-quality clinical scientific and regulatory outcomes.

• Collaborate closely with R&D and external partners to align clinical strategies with corporate priorities manufacturing capabilities and development plans.

• Lead the preparation review and submission of critical regulatory documents (e.g. protocols Investigators Brochures) to enable efficient early-phase clinical development.

• Cultivate and maintain relationships with Key Opinion Leaders (KOLs) academic investigators advisory boards CROs and trial sites.

• Engage effectively with investors board members and external stakeholders to communicate program progress scientific rationale and strategic value.

Essential Qualifications

• Education: MD with board certification in a relevant specialty (e.g. oncology nuclear medicine radiation oncology or related therapeutic area).

• 15 years of progressive clinical leadership experience in the biotech or pharmaceutical industry with a demonstrated track record of successfully advancing novel therapeutics from preclinical/early clinical stages through pivotal development.

• Proven expertise in global regulatory interactions including successful submissions negotiations and approvals with major agencies (FDA EMA and others) across early and late-stage programs.

• Prior experience in a CMO senior VP of Clinical Development or equivalent medical leadership role in a biotech or pharmaceutical organization ideally in a fast-paced innovative environment.

• Hands-on execution-oriented mindset with a willingness to actively contribute to pipeline advancement including protocol design data interpretation and cross-functional problem-solving.

• Exceptional scientific judgment strategic thinking and communication skills

Preferred Qualifications

• Expertise with drug conjugates (i.e. peptide-drug conjugates ADCs) and/or radioligand programs

What We Offer
At TwoStep Therapeutics we envision a future where every cancer patient has access to targeted safe and effective therapeutic options. We prioritize a diverse inclusive work environment that fosters personal and professional growth. Our comprehensive benefits include:

• Competitive base salary performance bonuses and equity compensation

• Unlimited Paid Time Off (PTO)

• Comprehensive medical dental and vision benefits for individuals and families

• 401(k) plan

• Company-paid basic life insurance

Equal Opportunity Employer
TwoStep Therapeutics is an equal opportunity employer. We prohibit unlawful discrimination based on race color religion gender sexual orientation gender identity/expression national origin/ancestry age mental/physical disability medical condition marital status veteran status or any other characteristic protected by law. If you require assistance in submitting an application due to incompatible assistive technology or a disability please contact us at We are committed to accommodating your needs promptly.

Join Us
If you are passionate about advancing cancer therapies and want to make a meaningful impact in the field we invite you to apply for the Chief Medical Officer position at TwoStep Therapeutics. Together we can shape the future of cancer treatment.

Required Experience:

Chief