Intern – Medicinal Chemistry

Cytokineticsis a specialty cardiovascular biopharmaceutical company building on its over 25 years of pioneering scientific innovations in muscle biology and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.

At Cytokinetics each team member plays an integral part in advancing our mission to improve the lives of patients. We are seeking tenacious compassionate and collaborative individuals who are driven to make a positive impact.

At Cytokinetics we are dedicated to supporting the next generation of biotech professionals through our annual Cytokinetics Internship Program. We believe that investing in enthusiastic students and recent graduates brings fresh perspectives and insights to our teams and we take pride in providing opportunities to contribute to meaningful projects. Through our Internship Program we aim to provide a challenging and rewarding experience to build a strong foundation for a career in the biopharmaceutical industry.

Project Description

• Support a hit-to-lead medicinal chemistry project aimed at improving the potency and selectivity of small-molecule inhibitors against a defined biological target

• Explore structure-activity relationships (SAR) around a lead scaffold to inform synthetic design

• Evaluate compounds in biochemical and/or cellular assays and data to guide iterative design decisions

• Assists in optimizing physicochemical and early ADME properties (solubility stability) under guidance from project scientists

Responsibilities

• Participate in the design synthesis purification and characterization of novel biologically active molecules

• Apply in-silico machine learning models to inform compound design

• Contribute to exploratory research and lead optimization projects and collaborate closely with colleagues in other groups

• Summarize/interpret data and present findings in research meetings

Qualifications

• Upcoming 3rd or 4th year PhD student preferred.

• Bachelors degree in chemistry required.

• Prior synthetic organic chemistry lab experience strongly required.

• Demonstrated expertise in organic synthesis chromatographic purification. methods and compound characterization using modern analytical techniques (NMR MS HPLC etc.).

• Organized detail-oriented excellent record-keeping skills excellent verbal and written communication skills.

• Ability to work independently and perform well in a team environment.

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Pay Range:

Our employees come from different backgrounds and we celebrate those differences. We are looking for the best candidates for our open roles but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team we would love to hear from you.

Please review ourGeneral Data Protection Regulation (GDPR) policyPRIOR to applying.

Our passion is anchored in robust scientific thinking grounded in integrity and critical thinking. We keep the patient front and center in all we do all actions and decisions are in service of the patient and their caregivers. We champion integrity ethics doing the right thing and being our best selves.

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Cytokinetics is an Equal Opportunity Employer