Director of Pharmacometrics
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Job Location:
Redwood City, CA - USA
Monthly Salary:
Not Disclosed
Posted on:
Yesterday
Vacancies:
1 Vacancy
Job Summary
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team you will join other outstanding Revolutionariesin a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
We are seeking a passionate and experienced individual with strong statistical modeling background to be part of the Nonclinical Development and Clinical Pharmacology (NDCP) Organization.
As a key member of the pharmacometrics group you will:
Develop and apply advanced statistical and machine learning methodologies to address complex scientific questions in PK/PD and exposure-response analysis.
Design and implement model-based meta-analysis (MBMA) frameworks to integrate internal PKPD data and external data to inform clinical pharmacology strategies.
Provide statistical and quantitative modeling support for key development decisions including dose optimization and RP2D selection.
Collaborate cross-functionally to ensure modeling approaches are scientifically rigorous fit-for-purpose and aligned with program objectives.
Contribute to the continuous advancement of quantitative science capabilities including method development best practices and adoption of innovative analytical approaches.
Required Skills Experience and Education:
PhD in Statistics/Biostatistics Pharmaceutical Sciences or MS in Statistics with five years of experience in MBMA in pharmaceutical industry.
Solid knowledge and hands-on experience in hierarchical models and Bayesian inference are required.
Solid knowledge and hands-on experience in standard statistical modeling (generalized linear models survival models mixed models etc) are required.
Demonstrated experience in meta-analysis including the application of appropriate statistical methods to model between-study variabilities.
Proficiency in statistical programming using R.
Excellent verbal and written communication skills and ability to clearly convey complex concepts and findings to both non-specialist and specialist audiences.
Experience and track record in clinical-stage drug development.
Preferred Skills:
Prior experience with small molecules in oncology drug development.
Local candidates are preferred but strong remote candidates will be considered.
#LI-Hybrid #LI-CT1
The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role level and location. Individual base pay salary is determined by multiple factors including job-related skills experience market dynamics and relevant education or training.
Please note that base pay salary range is one part of the overall total rewards program at RevMed which includes competitive cash compensation robust equity awards strong benefits and significant learning and development opportunities.
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race color religion gender sexual orientation gender identity/expression national origin/ancestry age disability marital status medical condition and veteran status.
Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect process and use any personal data that you provide to us in accordance with ourCCPA additional information please contact.
Required Experience:
Director
Key Skills
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