Senior Scientist II, Analytical Chemistry- Predictive Stability and Structure Elucidation

AbbVie Analytical Research & Development (Analytical R&D) is a global analytical scientific organization responsible for all CMC analytical activities related to the development of AbbVies pharmaceutical scope includes AbbVies diverse pipeline of innovative small molecule medicines and spans from the selection of Discovery candidate molecules to Late Stage are building a world-class team of scientists and leaders who will drive the advancement of industry-leading analytical capabilities and make meaningful contributions to advance AbbVies pipeline of innovative in AbbVie Analytical R&D provide unique opportunities to work with global and cross-functional teams to drive exceptional science and innovative product development are looking for diverse candidates with strong scientific experience to join the AbbVie Analytical R&D team and can offer exciting and rewarding career opportunities for these candidates. 

For the Senior Scientist II position we are seeking a highly motivated candidate who can conceive implement and execute novel scientific research and development. Generate new scientific proposals and lead these efforts. Act as a lead scientist in his/her area of expertise and critically evaluate relevant scientific and regulatory advances and integrate this knowledge into research and development programs. As part of the Predictive Stability and Structure Elucidation team they will collaborate with analytical and cross-functional teams to build the understanding of stability attributes and degradation pathways for synthetic molecule APIs.

He/she should possess an understanding of core discipline and support early phase development of New Chemical Entities (NCEs) drug substance and drug product in both preclinical and clinical programs. Collaborate within the global Analytical R&D organization and with R&D cross-functional partners such as Pre-Clinical Safety (PCS) Process Chemistry Process Engineering Drug Product Development (DPD) and Quality Assurance (QA) and CMC-Regulatory. 

Responsibilities:

• Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical products to further the understanding of emerging cGMP manufacturing processes.
• Responsible for leading the predictive stability aspects of a project while working with other functional areas to advance projects through the development pipeline.
• Utilize understanding of a range of analytical techniques to conduct research and development studies related to small-molecule drug products active pharmaceutical ingredients intermediates starting materials impurities and impurity profiling.
• Support new product development with advanced methods development and validations technical transfer packages and generation of technical data in support regulatory requirements.
• Highly autonomous and productive in performing laboratory research or method development requiring only minimal direction from or interaction with supervisor.
• Formulate conclusions and design follow-on experiments based on multidisciplinary data.
• May initiate new areas of investigation that are scientifically meaningful reliable and can be incorporated directly into a research or development program.
• Process interpret and visualize data to facilitate project team decisions.
• Communicate and collaborate with cross-functional groups and departments.
• Routinely demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
• Responsible for method development testing procedures and implementation of analytical control strategies to help the advancement of drug discovery candidates.
• Raises the bar and is never satisfied with the status quo.
• Understand and adhere to corporate standards regarding code of conduct safety appropriate handling of materials controlled drug and radioactive compounds and GxP compliance where applicable.

Qualifications :

• Bachelors Masters or Ph.D. in Analytical Chemistry typically with a minimum of 12 (BS) 10 (MS) or 4 (Ph.D.) years related industry experience.
• Practical understanding of organic chemistry reactions as related to potential degradation mechanisms of small molecules and peptides
• Experience with structure elucidation for small molecules particularly by high resolution mass spectrometry (Orbitrap QTOF etc). Experience developing LC-MS methods for trace quantitation is a plus.
• Some experience using computational tools to model chemical processes or reactions
• Strong technical background in analytical chemistry excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.
• Hands on experience with HPLC analysis and method development along with expertise and fundamental understanding of spectroscopic techniques.
• Self-motivated hard-working detail-oriented individual able to work in a fast-paced team environment.
• Experience in the use of computerized data handling systems.
• High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.
• Practical knowledge of organic structure functional groups chemistry and modern spectroscopic techniques as applied to small-molecule analytical analysis.
• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
• Learns fast grasps the essence and can change course quickly where indicated.
• Creates a learning environment open to suggestions and experimentation for improvement.
• Embraces the ideas of others nurtures innovation and manages innovation to reality.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this postingbased on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately paymore or less than the posted range. This range may be modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our short-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commissionincentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and untilpaid and may be modified at the Companys sole and absolute discretion consistent with applicable law. 

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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Work :

No

Employment Type :

Full-time