Scientist II, DMPK

Redwood City, CA - USA

Monthly Salary: Not Disclosed

Posted on: 22 hours ago

Vacancies: 1 Vacancy

Job Summary

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team you will join other outstanding Revolutionariesin a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

The DMPK Scientist will be a key member of the Drug Metabolism and Pharmacokinetics (DMPK) team within the Nonclinical Development and Clinical Pharmacology (NDCP) department.

Design and execute in vitro and in vivo metabolite identification studies using liver microsomes hepatocytes recombinant enzymes and biological samples (blood plasma tissue urine bile etc.) and perform metabolite profiling and structural elucidation.
Characterize major unique or disproportionate metabolites to support candidate selection MIST (Metabolites in Safety Testing) analysis and metabolite regulatory strategy.
Design and perform mechanistic studies to understand metabolic pathways and enzyme kinetics; work with pharmaceutical product teams to characterize drug degradation products and impurities.
Develop and apply PBPK models to predict human DDI risk potential using preclinical dataset; support regulatory interactions related to PBPK-based DDI modeling strategies.
Author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies.
Build and maintain strong collaborative partnerships across functional areas e.g. Discovery research Clinical Pharmacology Medicinal Chemistry Pharmaceutical Development Toxicology and Translational Research.

Required Skills Experience and Education:

A highly motivated individual with a PhD in Pharmaceutical Sciences Chemistry Biochemistry or related field with > 2 years of experience after graduation.
Demonstrated hands-on experience in metabolite profiling using high resolution mass spectrometry.
Solid understanding of drug metabolism pharmacokinetics and ADME principles.
Excellent verbal and written communication problem-solving and critical thinking skills.
Ability to independently design experiments analyze data and communicate results.

Preferred Skills:

Prior experience with oncology drug discovery is preferred.
Familiar with PBPK modeling software (e.g. WinNonlin Simcyp Gastroplus).
Effective communication and documentation skills.
#LI-Hybrid #LI-CT1

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role level and location. Individual base pay salary is determined by multiple factors including job-related skills experience market dynamics and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed which includes competitive cash compensation robust equity awards strong benefits and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race color religion gender sexual orientation gender identity/expression national origin/ancestry age disability marital status medical condition and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect process and use any personal data that you provide to us in accordance with ourCCPA additional information please contact .

Base Pay Salary Range

$132000$166000 USD

Required Experience:

The Opportunity:

The DMPK Scientist will be a key member of the Drug Metabolism and Pharmacokinetics (DMPK) team within the Nonclinical Development and Clinical Pharmacology (NDCP) department.

Design and execute in vitro and in vivo metabolite identification studies using liver microsomes hepatocytes recombinant enzymes and biological samples (blood plasma tissue urine bile etc.) and perform metabolite profiling and structural elucidation.
Characterize major unique or disproportionate metabolites to support candidate selection MIST (Metabolites in Safety Testing) analysis and metabolite regulatory strategy.
Design and perform mechanistic studies to understand metabolic pathways and enzyme kinetics; work with pharmaceutical product teams to characterize drug degradation products and impurities.
Develop and apply PBPK models to predict human DDI risk potential using preclinical dataset; support regulatory interactions related to PBPK-based DDI modeling strategies.
Author and review DMPK sections of regulatory submissions and respond to questions from regulatory agencies.
Build and maintain strong collaborative partnerships across functional areas e.g. Discovery research Clinical Pharmacology Medicinal Chemistry Pharmaceutical Development Toxicology and Translational Research.

Required Skills Experience and Education:

A highly motivated individual with a PhD in Pharmaceutical Sciences Chemistry Biochemistry or related field with > 2 years of experience after graduation.
Demonstrated hands-on experience in metabolite profiling using high resolution mass spectrometry.
Solid understanding of drug metabolism pharmacokinetics and ADME principles.
Excellent verbal and written communication problem-solving and critical thinking skills.
Ability to independently design experiments analyze data and communicate results.

Preferred Skills: