AstraZeneca is a global science-led patient-focused biopharmaceutical company that focuses on the discovery development and commercialization of prescription medicines for some of the worlds most serious diseases! We are more than one of the worlds leading pharmaceutical companies.

AstraZeneca has an engaging environment that cultivates collaboration and innovation. We attract top minds and we cultivate and build talent.

Within Hematology R&D we are committed to advancing the science to deliver life changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology Tumor Drivers and Resistance DNA Damage Response Antibody-drug Conjugates Cell Therapy and Epigenetics) to help address unmet clinical needs in a host of hematological cancers we are motivated by a dedication to the scientific discovery and collaboration that will one day help eliminate cancer as a cause of death. This unit has responsibility for the value chain from discovery through to late-stage development enabling rapid acceleration of promising early-stage assets and life-cycle management programs

Translational Medicine (TM) overview

Translational Medicine transforms hematological cancer biology into actionable insights for therapeutic development and clinical decision-making within the Oncology space. Operating within the Hematology R&D division TM is responsible for delivering innovative strategic biomarker studies to support Hematology & Oncology project teams to make decisions. The TM team collaborates closely with preclinical bioscience and discovery early clinical development and precision medicine & Biosamples functions. TM provides robust scientifically driven biomarkers for all Hematology projects covering leukemia lymphoma and myeloma. This includes assay development technical validation and biomarker analysis for clinical samples. TM conducts translational research across early and late-phase clinical engagements integrating advanced biomarker strategies to enhance therapeutic outcomes. The Translational Research (TR) group is responsible for delivering laboratory assay development across our drug programs and impactful translational insights across our high priority cancer types

Key Responsibilities and Accountabilities

The Associate Director plays an integral role leading a small team in the development of translational assays delivery of translational data and hands-on execution of critical translational experiments and projects that support the Heme Translational Medicine Departments strategy. This includes clinical trial support pre-clinical drug development and cross-indication delivery. The Associate Director will have a special focus on supporting programs in multiple myeloma and blood cancer precursor conditions.

• The AD is responsible for the design and execution of non-clinical and translational experiments to understand hematological tumor biology supporting the AZ portfolio. This work includes but is not limited to testing target expression after treatment novel MRD technologies reverse translation approaches to identify mechanisms of resistance and informing new combinations across multiple heme indications.
• This role will lead translational assay development supporting programs in multiple myeloma and blood cancer precursor conditions as well as other heme malignancies indications.
• Integrate Translational Medicine Research Scientists with broader drug development teams including translational medicine (TM leads data scientists etc.) discovery and clinical groups.
• Manage a team of lab-based scientists to support Hematology Translational Medicine research efforts.
• Apply literature reviews protocols networking and prior laboratory experience to advance clinical and pre-clinical aims of the Hematology Translational Medicine group.
• Demonstrate excellent organizational and communication skills for cross-functional interactions.
• Writes research papers abstracts technical reports regulatory documents and SOPs.
• Performs all duties in compliance with internal SOPs and external regulations.

Minimum Requirements

• Doctorate degree in immunology molecular biology or related field with experience in hematology-oncology.
• Minimum of 5 years of industry experience including managerial experience of junior scientists and technicians.
• Strong background in oncology cell biology immunology and small molecule drug discovery ADCs cell therapies or TCEs.
• Strong hands-on experience with translational lab methodologies applicable to biomarker studies in pre-clinical models and clinical trials (eg. NGS flow cytometry qPCR etc) including data analysis of large datasets.
• Collaborating with clinical teams and working with clinical trial samples including for e.g. peripheral blood and bone marrow. Knowledge of clinical protocol design and biospecimen logistics.
• Robust track record of scientific achievement and innovation approaches as evidenced by publication record.
• Excellent interpersonal skills ability to work as an integral member of a team and proficiency in training and manging a team.
• Strong written and oral communication skills.
• Proven excellence in designing executing and interpreting cancer biomarker studies in preclinical models and clinical trials including biomarker development validation and clinical application.

The annual base pay for this position ranges from $134578.40 to $201867.60. Our positions offer eligibility for various incentivesan opportunity to receive short-term incentive bonuses equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs paid time off (i.e. vacation holiday and leaves) as well as health dental and vision coverage in accordance with the terms of the applicable plans.

Why AstraZeneca

When we put unexpected teams in the same room we ignite bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work at pace and challenge perceptions. Thats why we work on average a minimum of three days per week from the office. But that doesnt mean were not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

AstraZeneca offers an environment where innovation thrives. Our commitment to eliminating cancer as a cause of death drives us to challenge the status quo and deliver more effective treatments. With access to industry-leading research technology and a pipeline like no other you will be empowered to accelerate your career while making a meaningful impact on patients lives. Our entrepreneurial spirit encourages you to step up take accountability and lead changes in our dynamic environment. Together we are reshaping healthcare systems through collaboration innovation and advocacy.

Ready to make a difference Apply now and be part of our journey to redefine cancer treatment!

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Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.