Technical Project Manager

Company Description

Guardant Health is a leading precision oncology company focused on guarding wellness and giving every person more time free from cancer. Founded in 2012 Guardant is transforming patient care and accelerating new cancer therapies by providing critical insights into what drives disease through its advanced blood and tissue tests real-world data and AI analytics. Guardant tests help improve outcomes across all stages of care including screening to find cancer early monitoring for recurrence in early-stage cancer and treatment selection for patients with advanced cancer. For more information visitand follow the company onLinkedInX (Twitter)andFacebook.

We are seeking an experienced Technical Project Manager (based out of our Palo Alto CA office) to lead the development release and delivery of EMR/EHR integration solutions that connect our precision oncology platforms to healthcare provider this pivotal role you will enable oncologists and care teams to receive real-time actionable genomic insights within their existing clinical workflows. Youll drive agile execution coordinate complex interoperability projects and ensure every integration meets the highest standards of accuracy compliance and security. You will collaborate closely with engineering product bioinformatics security compliance and external healthcare partners to enhance data interoperability between precision oncology systems and EHR platforms such as Epic Cerner Athenahealth and Allscripts.

Agile Delivery & Scrum Leadership

• Lead agile teams developing APIs integration middleware and FHIR-based data services connecting oncology software to EMR/EHR systems.
• Facilitate all scrum ceremonies (sprint planning stand-ups reviews retrospectives) ensuring strong alignment between technical deliverables and clinical data requirements.
• Coach teams on Agile practice to improve delivery predictability and quality. Ensure integration features meet healthcare compliance standards (HIPAA HITRUST FDA 21 CFR Part 11).
• Collaborate with Product Owners integration engineers and healthcare IT stakeholders to define and prioritize integration backlogs.

Release Management

• Own the release lifecycle for EMR/EHR integrations from planning and validation to deployment and monitoring.
• Coordinate cross-functional testing with QA Clinical Operations and external EHR vendors.
• Maintain integration release calendars regression plans and change management documentation.
• Communicate release scope timelines and risks to stakeholders across engineering compliance and partner organizations.

Technical Project Management

• Manage technical projects that support bi-directional integration between oncology diagnostic systems and provider EHRs.
• Define scope milestones and success metrics for data exchange initiatives (lab results delivery order entry patient matching).
• Partner with internal and external teams to design scalable secure and standards-compliant interfaces.
• Oversee development and deployment of APIs and microservices supporting interoperability with major EMR/EHR vendors.
• Ensure documentation and validation artifacts support audit and regulatory readiness.
• Utilize JIRA Confluence and similar tools to manage technical tasks track dependencies and report progress.

Required Qualifications

• Bachelors degree in computer science Information Systems Engineering or related field.
• 8 years of experience in software delivery technical project management or release management within healthcare IT or diagnostics.
• Proven track record leading Agile teams delivering EMR/EHR integration or healthcare interoperability solutions.
• Understanding of EHR systems such as Epic Cerner Athenahealth or Allscripts and their integration frameworks.
• Familiarity with cloud-based architecture (AWS GCP) and CI/CD pipelines for healthcare applications.
• Strong communication and stakeholder management skills across technical and clinical domains.
• Exceptional organizational skills and attention to detail particularly around data integrity and compliance documentation.
• Proactive communicator comfortable managing cross-functional and vendor-facing relationships.
• Adaptable and calm under pressure when managing multiple releases and dependencies.

Preferred Qualifications

• Certified Scrum Master (CSM) SAFe Agilist or PMP certification.
• Experience in oncology genomics or diagnostic data systems.
• Familiarity with SMART on FHIR apps and healthcare API gateway management. Knowledge of regulatory standards such as HIPAA HITRUST CLIA CAP and FDA 21 CFR Part 11.
• Experience with validated software processes under a Quality Management System (QMS).
• Exposure to laboratory information systems (LIS/LIMS) and clinical order/result workflows.

Hybrid Work Model: This section is applicable to onsite employees who are eligible for hybrid work location as specified by management and related policies. Guardant has defined days for in-person/onsite collaboration and work-from-home days for individual-focused time. All U.S. employees who live within 50 miles of a Guardant facility will be required to be onsite on Mondays Tuesdays and Thursdays. We have found aligning our scheduled in-office days allows our teams to do the best work and creates the focused thinking time our innovative work requires. At Guardant our work model has created flexibility for better work-life balance while keeping teams connected to advance our science for our patients.