Senior Scientist xRNA sIRNA Discovery (80-100)

Basel - Switzerland

Monthly Salary: Not Disclosed

Posted on: 3 days ago

Vacancies: 1 Vacancy

Job Summary

Job Description Summary

Location: Basel Switzerland
Full time onsite #LI-onsite

Join our xRNA Team in Biomedical Research in Basel and help shape the future of RNA therapeutics. We are developing the next-generation siRNA medicines with the ambition to transform the lives of patients with unmet medical needs. This is an opportunity to bring your scientific talent and curiosity into a highly collaborative innovation-driven environment where your work will directly impact the discovery and development of breakthrough therapies.

We are looking for a lab-based Senior Scientist who thrives in high-energy teams loves solving challenging problems and has a strong background in biological research and RNA biochemistry. If youre passionate about developing and optimizing methods workflows and best practices that advance siRNA discovery we want you on our team.

Job Description

Key Responsibilities

Independently design plan and execute siRNA screening experiments using mammalian and primary cell culture including cell-based transfection assays qPCR and reporter-based readouts.
Develop optimize and validate novel biochemical and cell-based assays to support siRNA discovery and optimization.
Contribute to automated workflows using liquid-handling robotics platforms (e.g. for assay miniaturization screening and sample preparation).
Drive continuous improvement in lab organization workflows equipment implementation and adoption of new technologies.
Collaborate effectively with an interdisciplinary team in a matrix environment and present data and conclusions clearly in both verbal and written form.
Maintain high-quality records in electronic lab notebooks; analyze interpret and report results in a timely manner.

Minimum Requirements

MS or a Bachelors/scientific apprenticeship with at least 5 years of industry experience or recent graduate PhD with 0-1 years of industry experience in biochemistry cell biology or related fields.
Ideally a minimum of 3-5 years of laboratory research experiencein a pharma and/or biotech industry setting.
Strong hands-on experience in cell and molecular biology techniques including:
- Mammalian and primary cell culture
- mRNA and protein isolation characterization and quantification (e.g. familiarity and working knowledge of likes of qPCR CLIP IP (Immuno Precipitation) ELISA Western blot)
- next-generation sequencing workflows (e.g. NGS library preparation)
Experience with liquid-handling systems and automation of cell-based assays or a strong interest in developing such is a plus.
Proven ability to troubleshoot and refine assays to improve sensitivity robustness reproducibility and throughput.
Strong competence in MS Office applications (Excel Word Teams) electronic lab notebooks and data analysis software (e.g. GraphPad Prism Spotfire).
Excellent organizational skills attention to detail and strong verbal and written communication skills.
Ability to collaborate and thrive in a fast-paced team-oriented research environment.

Desirable Requirements

Familiarity with primary cell culture models (e.g. primary human or rodent cells).
Exposure to bioinformatics and coding ( for data processing visualization and analysis.
Experience with specific automation platforms () is a strong plus.

Additional Information

*Restrictions on flexible working may apply and are discretionary; these can be discussed during the interview process where applicable.

Accessibility and Accommodation

Novartis is committed to working with and providing reasonable accommodation to all individuals. If because of a medical condition or disability you need a reasonable accommodation for any part of the recruitment process or if you would like more detailed information about the essential functions of a position please send an e-mail to and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Skills Desired

Analytical Skill Analytical Skill Analytical Thinking Chemical Biology Chemistry Clinical Research Clinical Trials Collaboration Communication Skills Curious Mindset Data Data Analysis Design Of Experiments Detail-Oriented Diversity & Inclusion Drug Discovery Ethics Gene Therapy Immunology Laboratory Lifesciences Machine Learning (ML) Mammalian Cell Culture Medical Research Molecular Biology 11 more

Required Experience:

Senior IC

Job Description SummaryLocation: Basel SwitzerlandFull time onsite #LI-onsiteJoin our xRNA Team in Biomedical Research in Basel and help shape the future of RNA therapeutics. We are developing the next-generation siRNA medicines with the ambition to transform the lives of patients with unmet medical...