Post Doctoral Fellow-MSH
Share
Job Location:
New York City, NY - USA
Monthly Salary:
Not Disclosed
Posted on:
6 days ago
Vacancies:
1 Vacancy
Job Summary
Title:Postdoctoral Fellow TR05 (partially ISMMS funded)
Salary:$74692 total ($36000 external funding)
Department: Medicine/Nephrology
Physical work location:1468 Madison Avenue Annenberg 23-16 New York NY 10029
Name PI or Supervisor: John Cijiang He
Web link to Lab: link to Department: Contact: Irene Beaulieu; email:
Responsibilities
Background and Description of Research Project:
Diabetic kidney disease is the number one cause of kidney failure in the USA as well as in the world. Its underlined pathogenesis remains unclear and the treatment is limited. We have been using systems biology approach to study its pathogenesis in order to identify potential new drug targets to treat this disease. Recently we identified LRG1 as a key molecule involving in renal endothelial cell and tubular cell injury in diabetic kidney disease. The current project will focus on the role of LRG1 in the pathogenesis of diabetic kidney disease. We will use in vitro assays and in vivo animal models to confirm the critical role of LRG1 in kidney cell injury in diabetic kidney disease.
Technical Duties (include any protocols):
- Perform in vitro cell cultures of glomerular endothelial cells tubular endothelial cells and tubular epithelial cells and test whether overexpression or knockdown of LRG1 affects cell function and downstream signaling pathways.
- We have generated transgenic mouse models with overexpression or knockdown of LRG1 in endothelial cells and tubular cells. We will test whether these mice develop more or less kidney injury.
- Techniques include cell culture western blot qPCR genotyping of mice mouse breading kidney histology analysis immunostaining determination of urine albumin and renal function.
Qualifications
Educational and other Requirements for the position:Postdoc should have medical training (MD equivalent) or basic science training and is familiar with kidney disease pathogenesis (Nephrology training).
Experience Required:Candidate shouldhave basic training in medical research and know how to perform basic benchwork and animal studies.
Key Skills
- Teacher Coaching
- Public Health
- Google Docs
- Classroom Experience
- Systems Engineering
- Research Experience
- Teaching
- Grant Writing
- Leadership Experience
- Mentoring
- Public Speaking
- Writing Skills
About Company
Strength through Unity and Inclusion The Mount Sinai Health System is committed to fostering an environment where everyone can contribute to excellence. We share a common dedication to delivering outstanding patient care. When you join us, you become part of Mount Sinai’s unparalleled ... View more
