Postdoctoral Researcher (Molecular Mechanisms of Genetic Kidney Disorders)
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Job Location:
Monthly Salary:
Posted on:
8 hours ago
Vacancies:
1 Vacancy
Job Summary
Union: Non-Union
Number of Vacancies: 1
Site: Toronto General Hospital Research Institute
Department: Advanced Diagnostics
Reports to: Principal Investigator
Hours: 37.5 hours per week
Shifts: Day
Status: Temporary Full-time
Closing Date: 31 January 2025
The Barua Lab is seeking a highly motivated Postdoctoral Researcher for a full-time two-year position for the University Health Network (UHN). The successful applicant will join the laboratory of Dr. Moumita Barua investigating molecular mechanisms underlying genetic kidney disorders including Alport syndrome congenital anomalies of the kidney and urinary tract (CAKUT) and Joubert syndrome.
The laboratory is located in the research tower attached to Toronto General Hospital and is supported by peer-reviewed funding (CIHR Kidney Foundation of Canada) and philanthropic awards.
The Barua Lab integrates human genetics molecular biology and preclinical modeling to elucidate disease mechanisms and identify therapeutic targets. Genetic discoveries from patient and population cohorts guide the development of clinically relevant models in the lab. Major ongoing projects include:
- Genome-wide association studies of kidney traits
- Pax2 mediated kidney repair/regeneration - enthusiasm to work with mouse models is an asset
- Mechanistic studies in genetic kidney disease models including for Alport syndrome CAKUT and Joubert syndrome enthusiasm for working with mouse models is an asset
Duties
- Design and execute molecular biology experiments involving next-generation and single-cell sequencing workflows.
- Analyze and interpret large-scale multi-omics data including epigenomics transcriptomics and proteomics.
- Conduct preclinical studies using mouse models of kidney disease.
- Collaborate with laboratory scientists to validate and integrate findings.
- Prepare manuscripts presentations and scientific reports.
- Contribute to grant applications and progress reporting.
Qualifications :
- Within 1 year of PhD (or equivalent) graduation in molecular biology bioinformatics genomics biomedical sciences or a related field.
- Proven experience working with large datasets and performing statistical analyses.
- Proficiency in next-generation sequencing (WGS WES RNA-seq single-cell sequencing).
- Hands-on experience with single-cell sequencing technologies and associated analysis tools.
- Experience generating or analyzing proteomics data (e.g. mass spectrometry).
- Strong understanding of kidney disease biology or demonstrated interest in renal pathophysiology.
- Familiarity with mouse models including handling genotyping and phenotypic characterization.
- Experience in collaborative interdisciplinary research environments.
- Background in systems biology or network-based modeling (asset).
- Prior experience with translational research or preclinical models of kidney disease (asset).
Additional Information :
Why join UHN
In addition to working alongside some of the most talented and inspiring healthcare professionals in the world UHN offers a wide range of benefits programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor allowing you to find value where it matters most to you now and throughout your career at UHN.
- Competitive offer packages
- Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP access to Transit and UHN shuttle service
- A flexible work environment
- Opportunities for development and promotions within a large organization
- Additional perks (multiple corporate discounts including: travel restaurants parking phone plans auto insurance discounts on-site gyms etc.)
Current UHN employees must have successfully completed their probationary period have a good employee record along with satisfactory attendance in accordance with UHNs attendance management program to be eligible for consideration.
All applications must be submitted before the posting close date.
UHN uses email to communicate with selected candidates. Please ensure you check your email regularly.
Please be advised that a Criminal Record Check may be required of the successful candidate. Should it be determined that any information provided by a candidate be misleading inaccurate or incorrect UHN reserves the right to discontinue with the consideration of their application.
UHN is an equal opportunity employer committed to an inclusive recruitment process and workplace. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known.
We thank all applicants for their interest however only those selected for further consideration will be contacted.
Remote Work :
No
Employment Type :
Full-time
Key Skills
- Intelligence Community Experience
- Python
- Spss
- Microsoft Word
- R
- Regression Analysis
- Windows
- Stata
- Microsoft Powerpoint
- Research Experience
- Data Modeling
- Writing Skills
About Company
The University Health Network, where above all else the needs of patients come first, encompasses Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute and the Michener Institute of Education. The breadth of research, t ... View more
