Working Retiree ORP

Job Summary:

Key Responsibilities:

• Conduct mechanistic studies focused on molecular and cellular drivers of cardiac and vascular dysfunction particularly related to proteomic regulation and post-translational modification of sarcomeric proteins.

• Utilize and interpret results from a variety of cardiac disease models including mechanical injury (e.g. myocardial infarction) transgenic mouse models of progressive heart failure and large animal platforms.

• Perform cardiomyocyte and vascular smooth muscle isolation functional assays and mechanical analyses to evaluate contractility calcium sensitivity and biomechanical responses.

• Apply transcriptomic and proteomic tools to identify signaling pathways biomarkers and molecular phenotypes relevant to cardiovascular disease.

• Conduct protein expression and localization studies using methods such as western blotting immunohistochemistry ELISA and quantitative phosphorylation analysis.

• Prepare and analyze RNASeq datasets and integrate transcriptomic outputs with protein-level data to support mechanistic insights.

• Maintain meticulous laboratory records perform data interpretation write structured reports and contribute to presentations or manuscripts as needed.

• Collaborate with investigators trainees and interdisciplinary teams to advance research objectives and contribute expert consultation in cardiovascular physiology.

Why Join Us:

The Webb Waring Center at the University of Colorado Anschutz Medical Campus focuses on fundamental investigation of the causes and consequences of inflammation antioxidant deficiency and oxidative stress.

The Webb-Waring Center has a long tradition. Webb-Waring is historically tied to the Colorado and world research community for the better part of a century. Originally founded by Dr. Gerald B. Webb and Dr. James J. Waring in 1924 for the study of tuberculosis Webb-Waring focuses on innovative medical research and research is advancing understanding and improving the management of health and disease. The Webb-Waring Centers motivated staff and investigators strive to maintain the highest standard of research excellence and to provide a high level education that inspires and prepares students for careers in biomedical research and medicine.

Webb-Waring investigators are recognized for making the first clinical recognition of the Acute Respiratory Distress Syndrome (ARDS) and developing a commonly used diagnostic test of lung function. Currently Webb-Waring Center investigators are actively developing new diagnostic and therapeutic approaches for ARDS type 1 and type 2 diabetes multiple sclerosis (MS) fatty liver atherosclerosis traumatic brain injury (TBI) age-related macular degeneration (AMD) and aging.

Equal Opportunity Statement:

The University of Colorado (CU) is an Equal Opportunity Employer and complies with all applicable federal state and local laws governing non-discrimination in employment. We are committed to creating a workplacewhere all individuals are treated with respect and dignity andwe encourage individuals from all backgrounds to apply including protected veterans and individuals with disabilities.

Qualifications:

Minimum Qualifications:
Applicants must meet minimum qualifications at the time of hire.

• A Doctoral degree in biology or a directly related field from an accredited institution and 5 years of professional level experience working with rodents including breeding maintaining hemodynamics measurements and harvesting tissues

Preferred Qualifications:

• Demonstrated expertise in protein analysis including advanced western blotting immunohistochemistry ELISA and proteomic workflows.
• Experience with RNA sequencing (RNASeq) methods including sample preparation analysis and interpretation of transcriptomic data.
• Proficiency in proteomic and transcriptomic analysis including pathway analysis and integration of multi-omic datasets.
• Extensive experience with cardiac and vascular smooth muscle mechanical analysis including myocyte contractility tissue mechanics and biomechanical modeling.
• Strong foundational knowledge of cardiac hemodynamics cardiac structurefunction relationships and mechanisms of heart failure.
• Exceptional written and verbal communication skills with the ability to prepare scientific documents contribute to grant or manuscript development and communicate effectively within research teams.

How to Apply:

For full consideration please submit the following document(s):

1. A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position

2. Curriculum vitae / Resume

3. Three to five professional references including name address phone number (mobile number if appropriate) and email address

Applications are accepted electronically ONLY at should be directed to: Andy Poczobutt

Screening of Applications Begins:

Immediately and continues until December 16 2025.

Anticipated Pay Range:

The starting salary range (or hiring range) for this position has been established as

$60/hour

The above hiring range represents the Universitys good faith and reasonable estimate of the range of possible compensation at the time of posting. This position may be eligible for overtime compensation depending on the level.

ADA Statement:

The University will provide reasonable accommodations to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act please contact the Human Resources ADA Coordinator at .

Background Check Statement:

The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty staff students and visitors. To assist in achieving that goal we conduct background investigations for all prospective employees.

Vaccination Statement:

CU Anschutz strongly encourages vaccination against the COVID-19 virus and othervaccine preventable diseases. If you work visit or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work visit or volunteer addition if you work in certain research areas or perform certain safety sensitive job duties you must enroll in theoccupational health medical surveillance program.