Senior Scientist I, Cell-free Protein Synthesis

Somerville, NJ - USA

Monthly Salary: Not Disclosed

Posted on: Yesterday

Vacancies: 1 Vacancy

Job Summary

About Generate:Biomedicines

Generate:Biomedicines is a new kind of therapeutics company existing at the intersection of machine learning biological engineering and medicine pioneering Generative Biology to create breakthrough medicines where novel therapeutics are computationally generated instead of being discovered. The Company has built a machine learning-powered biomedicines platform with the potential to generate new drugs across a wide range of biologic modalities. This platform represents a potentially fundamental shift in what is possible in the field of biotherapeutic development.

We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions with an outsized opportunity for patients in need. We are seeking collaborative relentless problem solvers that share our passion for impact to join us!

Generate:Biomedicines was founded in 2018 by Flagship Pioneering and has received nearly $700 millionin funding providing the resources to rapidly scale the organization. The Company has offices in Somerville and Andover Massachusetts with 300 employees.

The Role:

Generate is seeking a highly creative and technologically curious Senior Scientist I in Cell-free Protein Synthesis to be part of the CFPS group in our prototyping lab. We believe innovations at the intersection of machine learning computational protein design and HTP experimentation will transform the ways that we bring new therapies to patients.

The Senior Scientist will contribute to efforts to expand our intrinsically scalable CFPS platform using synthetic biology ML-guided optimization and strain engineering with the aim of increasing throughput and dramatically shortening design-build-test-learn cycles of our therapeutic candidates. They will work to 1) further integrate CFPS technology into our HTP and Cryo-EM workflows combining synthetic biology structural biology automation and machine learning 2) optimize and expand our CFPS workflows across modalities and 3) work closely with our production scientists to design and implement productionized workflows.

The successful candidate has a proven track record of cross-disciplinary quantitative research combining deep understanding of synthetic biology and high-throughput experimentation. Close collaboration with members from Generates Protein Science Cryo-EM Computational and Machine Learning teams will be crucial to produce game-changing novel CFPS workflows. This is an opportunity to perform highly innovative technology development while being a part of the collaborative and premier scientific environment in a well-funded biotech startup.

Heres how you will contribute:

Expand Generates efforts to integrate CFPS into our HTP screening and Cryo-EM workflows.
Lead part of the team efforts to optimize CFPS workflows using both experimental tools (strain engineering synthetic biology automation Cryo-EM) and theory (computational analysis statistics and ML-guided optimization).
Work with production and analytics teams in the Protein Sciences department to optimize scaled-up workflows and implement characterization of CFPS-produced material.
Generate bold creative unconventional ideas and be a point person for intellectual property and patent writing.
Strategic experiment planning data interpretation summarization and presentation with minimum supervision are required
Involvement in accelerating the discovery engineering and characterization of novel biologics in the pipeline programs
Mentor and train scientists throughout the company.

The Ideal Candidate will have:

BSc/MSc with 10 years or PhD4 years of experience in a relevant science/engineering field (biophysics biochemistry physical chemistry biological engineering quantitative/synthetic biology or related discipline).
Demonstrated expertise in implementation analysis and optimization of Cell-Free Protein Synthesis systems.
Demonstrated experience in laboratory automation and high-throughput experimental design.
Deep subject matter expertise and experience with Cryo-EM is a plus
Experience with data analysis in Python Matlab R or equivalent is a plus
Highly motivated proactive and enthusiastic team player demonstrating flexibility and a sense of urgency

#LI-HM1

Generate:Biomedicines is committed to equal employment opportunity regardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Companys internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.

Compensation: The base salary range provided reflects our current estimate of what we anticipate paying for this position. Your actual base salary will be based on several factors including job-related skills experience internal equity relevant education or training and market addition you will be eligible for an annual bonus equity compensation and a competitive benefits package.

Per Year Salary Range

$124000$174000 USD

Required Experience:

Senior IC

About Generate:BiomedicinesGenerate:Biomedicines is a new kind of therapeutics company existing at the intersection of machine learning biological engineering and medicine pioneering Generative Biology to create breakthrough medicines where novel therapeutics are computationally generated instead ...