Senior Computational Biologist Translational and Clinical Biomarkers

Your work will change lives. Including your own.

The Impact Youll Make

As a key member of Recursions portfolio-facing data science team you will be at the forefront of reimagining drug discovery from first principles using Recursions massive data and compute capabilities. You will be the primary computational lead for multiple IND and clinical stage drug development programs and will be expected to use platform and patient data to advance our most promising therapeutic candidates through clinical trials.

You will be responsible for the evaluation of therapeutic hypotheses using internal and external data to identify candidate biomarkers to measure in translational studies and in phase I-II clinical trials. This is a highly collaborative role: you will partner with biologists clinicians platform and data engineers and translational experts to develop and scale methods that bring patient insights and reverse translation to the forefront of our medicines portfolio.

The ideal candidate has strong stakeholder management the ability to independently scope and prioritize with ambiguous or conflicting information and is motivated to look under every stone to do the right thing for patients.

In this role you will:

• Evaluate the molecular evidence for predictive and PD biomarker hypotheses in translational models and clinical samples (DNA RNA ctDNA and novel exploratory modalities)
• Pilot novel methods for patient stratification and indication selection or expansion
• Deliver biological insights on therapeutic candidates and disease biology from the analysis of high dimensional (phenomics transcriptomics patient-derived) datasets
• Present data analysis to decision makers and stakeholders in a clear and compelling way that drives toward getting medicines to patients
• Industrialize analysis approaches to not only solve for the current project but also accelerate future projects and scale the impact that we can have
• Collaborate cross-functionally with Recursions data science platform ML and clinical teams to further advance Recursions ability to leverage our own clinical data in meta-analysis hypothesis generation and reverse translation

The Team Youll Join

Our group is a bold agile diverse collective of computational drug discovery scientists deeply focused on the singular goal of bringing new therapeutics into the clinic at an accelerated pace. You will work extensively with scientists across the organization to advance milestones provide insights and drive decisions that advance Recursions capabilities and increase our likelihood of success. Essential attributes for this role include a bold execution-first attitude and passion for deploying rigorous science to develop life-changing medicines.

We partner closely with biologists translational scientists and clinicians to design and execute decisional data analysis for multiple programs. We are responsible for data strategy across the portfolio and are supported by computational leadership in designing scalable and reproducible experiments that advance multiple programs at once. Our team works closely with computational biologists in other therapeutic areas (neurobiology immunology and inflammatory diseases etc.) as well as data scientists and engineers from our core platform teams to provide a strong network of feedback and support.

The Experience Youll Need

• PhD in a relevant field (computational biology systems biology bioinformatics cancer biology immuno-oncology etc.) with a very strong computational focus and 3 years of experience in biotech or pharma industry OR MS in a relevant field and 5 years of experience in biotech or pharma industry solving fundamental problems in oncology or drug discovery
• Experience with high dimensional patient biomarker data from clinical trials in oncology
• Strong understanding of patient genetics and druggability of disease relevant pathways
• Experience applying computational methods (including probabilistic statistical and/or machine learning techniques) to analyze and integrate complex biological and/or human clinical data in a high level programming language such as Python or R
• Deep expertise in the analysis and data integration of two or more omics data modalities (phenomics transcriptomics proteomics genomics) including experience with matched clinical and molecular patient data
• Exceptional data visualization skills
• Excellent cross-functional communication skills including an ability to explain complex scientific concepts to a variety of audiences using a combination of plots documents and presentations

Nice To Have:

• Experience with late stage drug discovery and IND submission
• Experience collaborating cross-functionally with biometrics statistical sciences and clinical pharmacology departments

Working Location & Compensation:

This is an office-based hybrid role in either ourSalt Lake City UT or New York City NY offices. Employees are expected to work in the office at least 50% of the time.

At Recursion we believe that every employee should be compensated fairly. Based on the skill and level of experience required for this role the estimated current annual base range for this role is $151800 to $216300 (USD). You will also be eligible for an annual bonus and equity compensation as well as a comprehensive benefits package.

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The Values We Hope You Share:

• We act boldly with integrity. We are unconstrained in our thinking take calculated risks and push boundaries but never at the expense of ethics science or trust.
• We care deeply and engage directly. Caring means holding a deep sense of responsibility and respect - showing up speaking honestly and taking action.
• We learn actively and adapt rapidly. Progress comes from doing. We experiment test and refine embracing iteration over perfection.
• We move with urgency because patients are waiting. Speed isnt about rushing but about moving the needle every day.
• We take ownership and accountability. Through ownership and accountability we enable trust and autonomyleaders take accountability for decisive action and teams own outcomes together.
• We are One Recursion. True cross-functional collaboration is about trust clarity humility and impact. Through sharing we can be greater than the sum of our individual capabilities.

Our values underpin the employee experience at Recursion. They are the character and personality of the company demonstrated through how we communicate support one another spend our time make decisions and celebrate collectively.

More About Recursion

Recursion (NASDAQ: RXRX) is a clinical stage TechBio company leading the space by decoding biology to radically improve lives. Enabling its mission is the Recursion OS a platform built across diverse technologies that continuously generate one of the worlds largest proprietary biological and chemical datasets. Recursion leverages sophisticated machine-learning algorithms to distill from its dataset a collection of trillions of searchable relationships across biology and chemistry unconstrained by human bias. By commanding massive experimental scale up to millions of wet lab experiments weekly and massive computational scale owning and operating one of the most powerful supercomputers in the world Recursion is uniting technology biology and chemistry to advance the future of medicine.

Recursion is headquartered in Salt Lake City where it is a founding member of BioHive the Utah life sciences industry collective. Recursion also has offices in Toronto Montréal New York London Oxford area and the San Francisco Bay area. Learn more at or connect onX (formerly Twitter)andLinkedIn.

Recursion is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity national origin age disability veteran status or any other characteristic protected under applicable federal state local or provincial human rights legislation.

Accommodations are available on request for candidates taking part in all aspects of the selection process.

Recruitment & Staffing Agencies: Recursion Pharmaceuticals and its affiliate companies do not accept resumes from any source other than candidates. The submission of resumes by recruitment or staffing agencies to Recursion or its employees is strictly prohibited unless contacted directly by Recursions internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Recursion and Recursion will not owe any referral or other fees. Our team will communicate directly with candidates who are not represented by an agent or intermediary unless otherwise agreed to prior to interviewing for the job.