PhD (mfd) Project P06 RTG 3095 "Protective and pathogenic antibody responses at barrier organs"

The DFG-funded Research Training Group (RTG) 3095 Protective and pathogenic antibody responses at barrier organs is a collaborative doctoral programme jointly organized by the University of Lübeck and Kiel University two modern and research-intensive universities with strong profiles in medicine molecular biology and life sciences. Their study programmes have consistently achieved top rankings in the CHE Ranking the most comprehensive evaluation of study programmes at German universities.

Immunological barrier organs such as the skin intestine and lungs are continuously exposed to commensal microorganisms pathogens and environmental allergens. As a result infections as well as allergic and autoinflammatory disorders at these mucosal interfaces are frequent and represent a significant burden to public health. Antibody-mediated immune responses play a central role in maintaining homeostasis at these sites: they contribute to the control of pathogen invasion the regulation of gut microbiota and the initiation and modulation of allergic reactions while also exerting regulatory functions that can down regulate inflammation.

The overarching goal of RTG 3095 is to elucidate the mechanisms by which B cell responses are initiated maintained and contribute to either immunoprotection or immunopathogenesis at these immunological barrier sites. To achieve this the programme employs state-of-the-art experimental approaches including single-cell sequencing spatial transcriptomics and advanced molecular and immunological techniques. Doctoral researchers will benefit from a structured 4-year training programme that integrates cutting-edge research with comprehensive training opportunities.

Start in our team

Within this framework the subproject P06 Lung-resident B cells as producers of Immunoglobulin A led by Prof. Andreas Hutloff at the Institute for Immunology Kiel University is seeking a PhD Candidate to start on April 1 2026. The position is initially limited until March 31 2030.

What we offer you:

• Employment according to 65 % E 13 TV-L (German public sector pay scale) on a fixed-term contract until March 31st 2030
• Work in a strong international and interdisciplinary research team
• Participation in the structured qualification programme of RTG 3095 including workshops courses and summer schools in state-of-the-art immunology related research.
• A highly stimulating research environment with access to state-of-the-art technologies such as single-cell sequencing and spatial transcriptomics
• Excellent opportunities for scientific networking and qualification in cutting-edge immunological research

What you can expect:

• Conducting a doctoral research project within P06 focusing on the question of why and how IgA B cells are only generated in the lung tissue but not the lung-draining lymph node
• To generate a single cell interactome of murine IgA and IgG B cells in the lung and lymph node
• Active participation in the scientific programme of the RTGs graduate training activities
• Presentation and discussion of research findings within the research consortium

Your profile:

• A Masters degree (or equivalent) in the life sciences or a related discipline fulfilling the formal requirements for enrolment as a doctoral candidate at the University of Lübeck
• Excellent command of English
• Experience with mouse models flow cytometry and molecular and cellular biology techniques as well as knowledge of German are advantageous
• Motivation to apply bioinformatics approaches for the analysis of high-throughput datasets (e.g. scRNA-seq); experience with R or comparable statistical software is desirable
• Strong motivation to contribute your own ideas to a dynamic interactive research team and an independent structured and collaborative working style

Application:

Please include the following documents with your application:

• A motivation letter (maximum one page) which also indicates if you are also interested in other projects within the RTG 3095 (a maximum of 3 projects)
• A curriculum vitae (including a list of publications if applicable)
• Certificates and transcripts of your previous university degrees (BSc/MSc including transcripts of records)
• At least one letter of recommendation
• Names and email addresses of two potential references

Selection process

Application to this subproject of RTG 3095 is generally considered to be an application also to the other subprojects of RTG 3095. Separate application to another subproject is not required but please indicate in your motivation letter your favoured RTG3095 subprojects (see above motivation letter).

Among the written applications the most suitable candidates will be invited to a one-day symposium which will take place in January 2026 in Lübeck Germany.

We look forward to receiving your application by 14.12.2025 quoting reference number 27559.

Contact

Prof. Andreas Hutloff Institute for Immunology Kiel University

Email: