Postdoctoral Researcher positions-Kapahi lab

POSITION SUMMARY
Postdoctoral Researcher - Nutrient Signaling Circadian Rhythms & Neurodegeneration

The Kapahi Lab at the Buck Institute for Research on Aging is recruiting Postdoctoral Researchers to lead innovative projects exploring how circadian clocks and nutrient-responsive pathways influence eye and neuronal degeneration. These positions use bioinformatic and systems biology approaches to integrate findings from Drosophila and human data with a focus on conserved mechanisms in aging and age-related disease.

Our lab uses a cross-disciplinary toolkitgenetics pharmacology biochemistry and genomicsto understand how nutrition impacts the biology of aging. Model systems include C. elegans D. melanogaster and mammalian cells.

Why Join Us

• Work in a highly collaborative well-funded lab focused on translational aging research

• Access to state-of-the-art core facilities and rich model organism resources

• Strong mentorship with a track record of supporting K99/R00 applications

• Ideal for researchers seeking to transition to independent academic careers

QUALIFICATIONS

• PhD in Biology Bioinformatics Neuroscience or a related field.
• Experience with model organisms and/or bioinformatic data analysisis an advantage but not essential.
• Willingness to write grants and manuscripts is a prerequisite.

PUBLICATIONS

1. Bar S Wilson KA Dammer EB Schilling B Seyfried NT Ellerby LM Kapahi P. Neuronal glycogen breakdown exerts a neuroprotective effect in models of Alzheimers disease by enhancing flux through the pentose phosphate pathway. accepted Nat Metabolism 2025
2. Wilson KA Bar S Dammer EB Carrera EM Hodge BA Hilsabeck TAU Bons J Brownridge GW 3rd Beck JN Rose J Granath-Panelo M Nelson CS Qi G Gerencser AA Lan J Afenjar A Chawla G Brem RB Campeau PM Bellen HJ Schilling B Seyfried NT Ellerby LM Kapahi P. OXR1 maintains the retromer to delay brain aging under dietary restriction. Nat Commun. 2024 Jan 11;15(1):467. PMID: ; PMCID: PMC.
3. Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock. Sara Ahadi Kenneth A Wilson Jr Boris Babenko Cory Y McLean Drew Bryant Orion Pritchard Ajay Kumar Enrique M Carrera Ricardo Lamy Jay M Stewart Avinash Varadarajan Marc BerndlPankaj KapahiAli Bashir. Elife. 2023 Mar 28; restriction and clock delay eye aging to extend lifespan BA Meyerhof GT Katewa SD Lian T Lau C Bar S Leung NY Li M Li-Kroeger D Melov S Schilling B Montell CKapahi P. Nat Commun. 2022 Jun 7. & BENEFITS
   • The starting salary for a new postdoc at the Buck is $73760in 2026 with a range of up to $81440commensurate with postdoc level & experience.
   • Exciting dynamic work environment at the forefront of science using state-of-the-art techniques.
   • Generous benefits package including health insurance paid parental leave childcare assistance generous vacation/sick leave and 401(k) with 5% employer match and student loan repayment option.
   • Collaborative and dynamic environment both for science and social activities.

   ABOUT THE BUCK INSTITUTE
   Our success will ultimately change healthcare. At the Buck we aim to end the threat of age-related diseases for this and future generations by bringing together the most capable and passionate scientists from a broad range of disciplines to identify and impede how we age. We are an independent non-profit institution located in Marin County CA to increase human health span or the healthy years of life. Globally recognized as the pioneer and leader in efforts to target agingthe number one risk factor for diseases including Alzheimers Parkinsons cancer macular degeneration heart disease and diabetesthe Buck seeks to help people live better are an equal-opportunity employer and strive to create an atmosphere where diversity of identity experience and background is welcomed valued and supported. Candidates who contribute to this diversity are strongly encouraged to apply.

   TO APPLY
   Interested candidates should apply online and upload a CV cover letter and contact information for 3 professional references.

   For questions regarding this position please emailemailprotectedor visithttps://