Principal Scientist, MidLarge Scale Oligonucleotide Synthesis, xRNA Therapeutics

Basel - Switzerland

Monthly Salary: Not Disclosed

Posted on: 9 hours ago

Vacancies: 1 Vacancy

Job Summary

Job Description Summary

Location: Basel Switzerland #onsite

Role Purpose:
We are seeking a highly motivated and experienced PhD-level scientist to lead our mid/large xRNA synthesis team in Basel. This position requires extensive collaboration within a multidisciplinary environment bridging research and development to discover and advance innovative siRNA therapies addressing significant unmet medical needs.

Job Description

Key Responsibilities

Overseea state-of-the-art oligonucleotide synthesis facility managing both capital and consumables budgets efficiently.
Lead and guide a team of scientists specializing in oligonucleotide synthesis and purification of oligonucleotides at millimole scale to deliver on our growing siRNA portfolio
Ensure the delivery of high-quality siRNA products forboth in vitro screeningandin vivo evaluation within drug candidate pipelines.
Collaborate with discoveryxRNAexisting oligonucleotide synthesis teams in Basel as well as in Cambridge
Provide technical leadership to the scale-up team in the synthesis of oligonucleotides optimize methodologies and processes to improve efficiencies
Collaborate with synthetic chemists and project teams to scale up new siRNA chemistries thataddress critical scientificchallengesand facilitate their seamless transition into development.
Document and effectively communicate results and scientific insights to internal and external stakeholders through patent applications and scientific publications.
Mentor and support team members by sharing technical expertise and hands-on experience within the work environment.
Excellentproblemsolving skills and solution orientated mindset

Qualifications and Requirements

A PhD in synthetic chemistry focused on oligonucleotides.2-3 years experience in the industry setting
Proven practical experience in oligonucleotidesolid phasesynthesis and downstream processing with an expertise in a mid/large scale oligo synthesis and in process development.
Demonstrated leadership abilities and experience developing scientific teams.
Capacity to promote and implement innovative ideas within a global team context.
Strong independent problem-solving skills.
Proven collaborative attitude
Proficiency in managing multiple priorities effectively while maintaining focus where necessary.
Excellent verbal and written communication abilities.

Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding inclusive work environment and diverse teams representative of the patients and communities we serve.

Accessibility and accommodation
Novartis is committed to working with and providing reasonable accommodation to all individuals. If because of a medical condition or disability you need a reasonable accommodation for any part of the recruitment process or in order to receive more detailed information about the essential functions of a position please send an e-mail to and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Skills Desired

Required Experience:

Staff IC

Job Description SummaryLocation: Basel Switzerland #onsite Role Purpose:We are seeking a highly motivated and experienced PhD-level scientist to lead our mid/large xRNA synthesis team in Basel. This position requires extensive collaboration within a multidisciplinary environment bridging research an...

Job Description Summary

Job Description

Key Responsibilities

Overseea state-of-the-art oligonucleotide synthesis facility managing both capital and consumables budgets efficiently.
Lead and guide a team of scientists specializing in oligonucleotide synthesis and purification of oligonucleotides at millimole scale to deliver on our growing siRNA portfolio
Ensure the delivery of high-quality siRNA products forboth in vitro screeningandin vivo evaluation within drug candidate pipelines.
Collaborate with discoveryxRNAexisting oligonucleotide synthesis teams in Basel as well as in Cambridge
Provide technical leadership to the scale-up team in the synthesis of oligonucleotides optimize methodologies and processes to improve efficiencies
Collaborate with synthetic chemists and project teams to scale up new siRNA chemistries thataddress critical scientificchallengesand facilitate their seamless transition into development.
Document and effectively communicate results and scientific insights to internal and external stakeholders through patent applications and scientific publications.
Mentor and support team members by sharing technical expertise and hands-on experience within the work environment.
Excellentproblemsolving skills and solution orientated mindset

Qualifications and Requirements

A PhD in synthetic chemistry focused on oligonucleotides.2-3 years experience in the industry setting
Proven practical experience in oligonucleotidesolid phasesynthesis and downstream processing with an expertise in a mid/large scale oligo synthesis and in process development.
Demonstrated leadership abilities and experience developing scientific teams.
Capacity to promote and implement innovative ideas within a global team context.
Strong independent problem-solving skills.
Proven collaborative attitude
Proficiency in managing multiple priorities effectively while maintaining focus where necessary.
Excellent verbal and written communication abilities.