Principal Scientist, Cheminformatics (Small Molecule & DEL Informatics)

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at

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Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at & Johnson Innovative Medicine is hiring a Principal Scientist Cheminformatics to join our team. The US location options for this position are Spring House PA Cambridge MA and San Diego CA. Consideration may also be given for this position to be located in Beerse Belgium.

Please note that this role is available across multiple countries and may be posted under different requisition numbers to comply with local requirements. While you are welcome to apply to any or all of the postings we recommend focusing on the specific country that aligns with your preferred location:

USA - Requisition Number: R-026889

Belgium - Requisition Number: R-027978

We are seeking a highly skilled and innovative Principal Scientist in Cheminformatics to join our team. While strong emphasis will be put on informatics support for our DNA Encoded Library (DEL) platform the successful candidate will also play a broader role in establishing industry-leading small molecule informatics capabilities supporting bench scientists in every step of the DMTA cycle and guiding them in analysis and decision-making. This role will collaborate closely with project and platform teams to understand their ways of working and participate in the development of a future-looking informatics strategy for small molecules including data provisioning analytics and visualization for hit identification and compound optimization.

Key Responsibilities:

• Lead the development and implementation of advanced cheminformatics tools for small molecule analysis and DEL informatics.
• Implement statistical approaches to improve selection of compounds for off-DNA synthesis and accelerate workups of DEL screens.
• Enhance our internal DEL ML virtual screening capabilities and apply to key projects.
• Collaborate with interdisciplinary teams to integrate cheminformatics solutions into drug discovery platforms.
• Design and optimize computational workflows and front-ends for the analysis and visualization of small molecule bioactivity and ADMET data.
• Manage and mentor contractors ensuring robust project delivery and performance.
• Stay updated on industry trends and emerging technologies in cheminformatics and DEL to enhance project outcomes.

Required Qualifications:

• PhD in Cheminformatics Chemical Engineering Computational Chemistry or a related field.
• Minimum of 3 years of industry experience with a proven track record of delivering end-to-end solutions from conceptualization to implementation.
• Deep expertise in cheminformatics software (e.g. KNIME OpenEye) and programming languages (e.g. Python R).
• Expertise in structure-activity relationship (SAR) analysis
• Experience working in cross-functional teams & translating ideas from bench scientists to informatics solutions.
• Excellent problem-solving and communication skills with a collaborative mindset.

Preferred Qualifications:

• Good knowledge of DNA-encoded libraries and their applications in drug discovery.
• Experience with statistical analyses and machine learning techniques applied to chemistry problems.
• Experience managing contractors or direct reports.
• Experience leading strategic initiatives
• Experience in dashboarding (e.g. Spotfire streamlit shiny)
• Familiarity with medicinal chemistry end-user tools (e.g. LiveDesign).

This is a Hybrid role available in Spring House PA Cambridge MA or San Diego CA within the US or Beerse Belgium. (No fully remote option.) Travel up to approximately 10% may be required domestic and international.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation please contact us via or contact AskGS to be directed to your accommodation resource.

The anticipated base pay range for this position is $115000 to $197800. The Company maintains highly competitive performance-based compensation programs. Under current guidelines this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporations performance over a calendar/performance year. Bonuses are awarded at the Companys discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical dental vision life insurance short- and long-term disability business accident insurance and group legal insurance. Employees may be eligible to participate in the Companys consolidated retirement plan (pension) and savings plan (401(k)).

Employees are eligible for the following time off benefits:
Vacation up to 120 hours per calendar year
Sick time - up to 40 hours per calendar year
Holiday pay including Floating Holidays up to 13 days per calendar year of Work Personal and Family Time - up to 40 hours per calendar year
Additional information can be found through the link below. compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.

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