Post Doc Scientist- Oncology

At Gilead were creating a healthier world for all people. For more than 35 years weve tackled diseases such as HIV viral hepatitis COVID-19 and cancer working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the worlds biggest health challenges and our mission requires collaboration determination and a relentless drive to make a difference.

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Job Description

We are seeking a highly motivated and innovative Postdoctoral Research Fellow to join our oncology research team focused on establishing and understanding resistance mechanisms to small molecule cancer therapeutics in the in vitro and in vivo settings. The expectation is that the work will result in novel contributions to our understanding of resistance mechanisms and high-quality publications in top-tier scientific journals. The selected candidate will work in a highly collaborative environment at Gilead through a 2-year term with an option to extend an additional third year. It also provides access to world class research facilities and the opportunity to leverage expertise and resources across multiple functional areas at Gilead.

Key Responsibilities

• Develop and characterize in vitro and in vivo resistance models using cancer cell lines and mouse xenograft tumor models.

• Perform multi-omics profiling (WES RNA-seq methylation analysis and other) to identify molecular alterations associated with acquired and intrinsic resistance.

• Conduct functional validation of candidate resistance mechanisms using gene editing and gain-of-function systems.

• Think critically and creatively while applying strong organizational and planning skills

• Actively participate in cross-functional group collaborations present at company internal meetings as well as at national or international scientific conferences

Qualifications

• Ph.D. in Cancer Biology Molecular Biology Genetics or a related field.

• Strong background in cancer pharmacology drug resistance and functional genomics.

• Hands-on experience with CRISPR/Cas9 lentiviral systems and mouse xenograft models.

• Proficiency in next-generation sequencing data analysis and interpretation will be preferred.

• First authorship in publications in peer-reviewed journals or accepted in a peer-reviewed journal.

• Demonstrated ability to work independently and collaboratively in a multidisciplinary team.

• Excellent communication and scientific writing skills.

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Eligible employees may participate in benefit plans subject to the terms and conditions of the applicable plans.

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