Master Thesis Development of Synthetic Lymph Nodes to study Leukemia Therapy Resistance

Saarbrücken - Germany

Monthly Salary: Not Disclosed

Posted on: 21 hours ago

Vacancies: 1 Vacancy

Job Summary

INMs research group Immuno-Materials combines expertise from synthetic biology biomaterials and immunology to develop new approaches for studying and regulating immune reactions.

Are you a master student (f/m/d) with a background in cell biology biomaterials or biophysics (or related fields) and looking for a thesis project This might be something for you!

Master Thesis:

Development of synthetic lymph nodes to study leukemia therapy resistance

Starting on February 1st 2026 (with flexibility).

We have pioneered the development of synthetic lymph nodes formed from artificial cells that can mimics the microenvironment of leukemia cells. This approach can be applied to form artificial tumor microenvironments with defined properties and systematically study therapy resistance mechanisms. We are able to induce specific molecular and biophysical changes in the synthetic lymph nodes that mimic the signaling induced by the extracellular matrix and other immune cells in the lymph nodes. The master thesis should study the effects of the extracellular matrix in conjunction with intercellular signaling on therapy resistance of chronic lymphocytic leukemia.

Techniques applied include:

3D cancer cell culture
Immuno-staining with flow cytometry analysis
Advanced microscopy (light-sheet microscopy confocal fluorescence microscopy)
Biochemical and radiometric assays

Interested We are looking forward to receiving your application (CV . certificate or transcripts of record motivation letter) by December 15th 2025. Please send it via our online applications system (single pdf file < 5 MB).

The INM practices an open and appreciative corporate culture in which the existing diversity is promoted and lived. The institute is an equal opportunity employer with a certified family-friendly policy and it provides offers for a better work-life balance flextime and mobile working. We promote professional opportunities for women and strongly encourage them to apply. Severely disabled applicants with equal qualifications and aptitude will be given preferential consideration.

Required Experience: