Sr Scientist, Drug Metabolism
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Job Location:
Foster, CA - USA
Monthly Salary:
$ 169320 - 219120
Posted on:
12 hours ago
Vacancies:
1 Vacancy
Job Summary
At Gilead were creating a healthier world for all people. For more than 35 years weve tackled diseases such as HIV viral hepatitis COVID-19 and cancer working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the worlds biggest health challenges and our mission requires collaboration determination and a relentless drive to make a difference.
Every member of Gileads team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions and were looking for the next wave of passionate and ambitious people ready to make a direct impact.
We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future you are the key driver in evolving our culture and creating an environment where every employee feels included developed and empowered to fulfil their aspirations. Join Gilead and help create possible together.
Job Description
Specific Responsibilities:
The primary responsibility of thisBiologics DMPK Senior Scientistposition is to serve as an expert in pharmacokinetic (PK) and PK/PD modeling of biologics providing strategic and scientific leadership on large molecule discovery and development project teams. The role emphasizes the application of advanced quantitative approaches including mechanistic and empirical modeling to characterize and predict the absorption distribution metabolism and excretion (ADME) properties of protein therapeutics. Additionally responsibilities include designing and interpreting in vitro and in vivo studies integrating data into mathematical models and generating simulations to support dose selection and clinicaltranslation.Thisrole offers opportunities to serve as a project representative and departmental modeling expert while also contributing to business development initiatives and external collaborations.
Essential Duties and Job Responsibilities:
Provide advanced PK and PK/PD modelingexpertiseon project teams across discovery and development stages guiding the design and interpretation of nonclinical PK toxicology and pharmacology studies.
Lead quantitative DMPK strategyfor biologics programs collaborating with interdisciplinary teams to integrate modeling approaches into decision-making; communicate modeling insights and align strategies with scientists collaborators and management.
Design implement andvalidatecomplex PK/PD and mechanistic modelsto address translational questions support dose selection and predict first-in-human exposures.
Develop and refine modeling workflowsfor nonclinical study design including simulation-based approaches to optimize study parameters and interpret outcomes.
Prepare study protocols and coordinate execution of nonclinical studies which may involve multiple functional areas and CROs.
Work closely with project teamslinemanagementand CROs toassurehigh quality andtimelydelivery of written PK reports and regulatory documents (IND IMPD IB BLA) for regulatory submissions.
Participate in business development and licensing evaluations.
Basic Qualifications:
Bachelors Degree and8Years Experience
OR
Masters Degree and6Years Experience
OR
PhD/ PharmDand2Years Experience
OR
MD
Preferred Qualifications:
Ph.D. with 3 years of post-graduate industry experiencein pharmacokinetics drug metabolism pharmaceutics or a related life science field with a primary focus on quantitative modeling for large molecule/biologics PK characterization across discovery and development.
Strongfoundationin pharmacokinetics and pharmacodynamics principles withdemonstratedability to translate these concepts into mathematical models.
Extensiveexperience in mechanistic PK/PD and multi-compartmental modeling includingproficiencywith software platforms such asPhoenix/WinNonlin MATLAB/SimBiology R or equivalent modeling tools.
Provenability to design implement and interpret complex modeling workflowsdeterminenext steps based on quantitative insights and effectively communicate results to project teams and senior management.
Demonstratedintellectual curiosity and commitment to staying currentwith advances in biologics DMPK and modeling methodologies supported bya track recordof external visibility through publications presentations and/or professional organization involvement.
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Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment and is dedicated to fostering an inclusive work environment comprised of diverse perspectives backgrounds and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race color religion national origin sex age sexual orientation physical or mental disabilitygenetic information or characteristic gender identity and expression veteran status or other non-job related characteristics or other prohibited grounds specified in applicable federal state and local order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973 the Vietnam Era Veterans Readjustment Act of 1974 and Title I of the Americans with Disabilities Act of 1990 applicants who require accommodation in the job application process may contact for assistance.
For more information about equal employment opportunity protections please view theKnow Your Rights poster.
NOTICE: EMPLOYEE POLYGRAPH PROTECTION ACT
YOUR RIGHTS UNDER THE FAMILY AND MEDICAL LEAVE ACT
Gilead Sciences will not discharge or in any other manner discriminate against employees or applicants because they have inquired about discussed or disclosed their own pay or the pay of another employee or applicant. However employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information unless the disclosure is (a) in response to a formal complaint or charge (b) in furtherance of an investigation proceeding hearing or action including an investigation conducted by the employer (c) consistent with the legal duty to furnish information; or (d) otherwise protected by law.
Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.
Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.
For Current Gilead Employees and Contractors:
Please apply via the Internal Career Opportunities portal in Workday.
Required Experience:
Senior IC
Key Skills
- Laboratory Experience
- Immunoassays
- Machine Learning
- Biochemistry
- Assays
- Research Experience
- Spectroscopy
- Research & Development
- cGMP
- Cell Culture
- Molecular Biology
- Data Analysis Skills
About Company
Gilead Sciences is continuing to hire for all open roles. Our interview process may be conducted virtually and some roles will be asked to temporarily work from home. Over the coming weeks and months, we will be implementing a phased approach to bringing employees back to site to ensu ... View more
